海南粗榧内生真菌抗肿瘤抗菌活性的筛选  

Screening of Antitumor and Antimicrobial Activities of the Endophytic Fungi Isolated from Cephalotaxus hainanensis Li

作　　者：戴文君[1] 戴好富[1] 陈苹[1] 吴娇[1] 梅文莉[1] 

机构地区：[1]中国热带农业科学院热带生物技术研究所农业部热带作物生物技术重点开放实验室,海南海口571101

出　　处：《微生物学通报》2009年第8期1217-1221,共5页Microbiology China

基　　金：国家自然科学基金(No.30560018);973计划前期研究专项(No.2007CB116306)

摘　　要：对72株海南粗榧(Cephalotaxus hainanensis Li)内生真菌进行了抗肿瘤和抗菌活性筛选。结果显示,有9株内生真菌至少对一种指示瘤株具有细胞毒活性,5株内生真菌对金黄色葡萄球菌有较强的抑菌活性,1株内生真菌对辣椒疫霉有抑制作用。这表明海南粗榧内生真菌是寻找有价值的生物活性成分的潜在资源,其生物活性成分值得进一步研究。Seventy-two endophytic fungi isolated from Cephalotaxus hainanensis Li were screened for antitumor and antimicrobial activities. The results showed that 9 strains presented cytotoxic activities to at least one of the tested tumor cells, five strains exhibited strong antimicrobial activity against Staphylococcus aureus, one strain had inhibitory effect on Phytophthora parasitica. It was evidently that the endophytic fungi of C. hainanensis are potential resources to find valuable bioactive components.

关 键 词：海南粗榧 内生真菌 细胞毒活性 抗菌活性 

分 类 号：Q93[生物学—微生物学]