超微量肝素加大剂量维生素E对过敏性紫癜患儿氧化应激及微炎症状态的影响  

The effect of ultramicro-heparin and high-dose Vitamin E supplementation on oxidative stress and microinfiammation state in patients with HSP

作　　者：施学文 陈娟 王飞[3] 

机构地区：[1]江苏省泗洪儿童医院内科四病区,223900 [2]江苏省分金亭医院血液肿瘤科 [3]江苏省宿迁市人民医院检验科

出　　处：《中国小儿血液与肿瘤杂志》2009年第4期167-169,共3页Journal of China Pediatric Blood and Cancer

摘　　要：目的探讨超微量肝素加大剂量维生素E对过敏性紫癜患儿氧化应激及微炎症状态的影响。方法采用随机对照方法,将80例过敏性紫癜(HSP)患儿分为肝素治疗组(40例)和常规治疗组(40例),两组病例均给予相同的基础治疗,在此基础上肝素治疗组加用低分子肝素钙、皮下注射,肝素为6U/(kg.次),每6小时1次,连续应用5天,维生素E300mg/d,连续服用15天。观察两组病例治疗前后氧化应激及炎症指标的变化。结果肝素治疗组患者的各项氧化应激及微炎症指标均较常规治疗组明显改善,肾损害的发生率亦明显降低。结论超微量肝素加大剂量维生素E可明显改善过敏性紫癜氧化应激及微炎症状态,能预防或降低紫癜性肾炎的发生,具有显著的肾保护作用,能改善HSP的预后,未见明显副反应。Objective To investigate the effects of the oxidative stress and microinflammation state with uhramicro-heparin and high-dose Vitamin E supplementation in children with Henoch-Schonlein purpura （HSP）. Methods Eighty patients with HSP were enrolled in the study and divided randomly into two groups. Heparin group and conventional group. Two groups were treated by the same basic therapy. On which the heparin group 40 patients were administrated with calcium heparin subcutaneously with 24 IU/kg · d for five days and Vitamin E with 300 mg/d for fifteen days. Then we observed the change of the markers on oxidative and microinfiammation in two groups. Results All markers of oxidative stress and microinflammation state were signiifcantly improved in the patients of heparin group, ultramicro- heparin and high-dose Vitamin E supplementation tends to beneift patients for reducing risk to develop renal involvement. Conclusion Ultramicro-heparin and high-dose Vitamin E ameliorates oxidative stress and microinflammation state without apparent side effect and could significantly reduce the incidence of HSP nephritis （HSPN） and improve the prognosis of HSP.

关 键 词：肝素 维生素E 紫癜 过敏性 氧化应激 微炎症 

分 类 号：R725.5[医药卫生—儿科]