中国人内皮型一氧化氮合酶基因G894T多态性与原发性高血压关系的Meta分析  

Meta-analysis on the association of G894T polymorphism in endothelial nitric oxide synthase gene and essential hypertension in Chinese population

作　　者：王从菊[1] 赵景波[1] 许加亮[1] 向泽林[1] 梁长威[1] 李杰[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院流行病学教研室,150081

出　　处：《中华流行病学杂志》2009年第8期845-849,共5页Chinese Journal of Epidemiology

基　　金：黑龙江省卫生厅医学科研项目（2005-98）

摘　　要：目的综合评价中国不同地区人群内皮型一氧化氮合酶基因G894T（Glu298Asp）多态性与原发性高血压的关系。方法以高血压组和对照组基因型和等位基因分布的OR值为统计量，检索相关文献；应用MIX软件对各研究结果进行一致性检验和分析，并进行数据合并，评估发表偏倚的影响。结果共10篇文献纳入Meta分析，包括1900例原发性高血压患者和1216例对照者，10篇文献中高血压组与对照组（GT4-TT）／GG基因型频率和T／G等位基因频率OR值效应量的一致性检验结果均显著（P=0．013；P=0．011），并存在发表偏倚（P=0．049；P=0．038）。高血压组与对照组（GT4-TT）／GG基因型频率的合并OR值（95％CI）为1．79（1．33～2．42），显著性检验Z=3．83，P〈0．001。高血压组与对照组T／G等位基因频率的合并OR值（95％CI）为1．73（1．32—2．27），显著性检验Z=3．92，P〈0．001。结论中国人（汉族为主）内皮型一氧化氮合酶基因894G→T多态性与原发性高血压相关。Objective To evaluate the relationship between G894T （Glu298Asp） polymorphism in the endothelial nitric oxide synthase （eNOS） gene and essential hypertension in Chinese population from different regions. Methods Odds ratios （ORs） of G894T genotype and allele distributions in essential hypertension patients against healthy controls were analyzed. All the relevant studies were screened with poor-qualified studies eliminated. Meta-analysis software MIX （Meta-analysis with interactive explanations-version 1.71 ） , was applied for investigating and analyzing heterogeneity among individual studies and summarizing the effects across studies, and the risk of publication bias was evaluated. Results A total of 1900 cases and 1216 controls from 10 studies were included. The heterogeneity between studies was significant （P=0.013; P=0.011） and there were substantial sources of publication bias （P= 0.049; P= 0.038）. The pooled OR （with 95%CI） of GT ＋ TT vs. GG genotype was 1.79 （1.33-2.42）（Z=3.83,P〈0.001）, and the pooled OR （with 95%CI） ofT vs. G allele was 1.73 （1.32-2.27） （Z=3.92,P〈0.001）. Conclusion In Chinese population, mainly the Hans ethnic group, 894G→T mutation in the eNOS appeared to be related to essential hypertension.

关 键 词：高血压 内皮型一氧化氮合酶 META分析 

分 类 号：R544.1[医药卫生—心血管疾病] R972.6[医药卫生—内科学]