老年2型糖尿病患者血糖漂移与氧化应激的相关性研究  

Study on correlation between glucose excursions and oxidative stress in the elderly type 2 diabetic patients

作　　者：胡廷军[1] 钟远[1] 贾伟平[2] 章晓燕[1] 

机构地区：[1]上海交通大学附属第六人民医院老年科,200233 [2]上海交通大学附属第六人民医院内分泌科,200233

出　　处：《中华老年医学杂志》2009年第8期671-673,共3页Chinese Journal of Geriatrics

基　　金：中央保健专项资金科研课题（编号：192）

摘　　要：目的探讨老年2型糖尿病患者血糖漂移与氧化应激的关系。方法选择上海市第六人民医院老年科2型糖尿病住院的患者55例（男32例，女23例）为研究对象。患者人组当天佩戴动态血糖监测系统（CGMS），根据监测结果分为血糖高漂移组和血糖低漂移组。血糖高漂移组患者继续给予CGMS监测，并根据监测结果及时调整治疗方案，持续治疗4周。疗程结束后再次采血复查相关指标。结果（1）两组年龄、血压、空腹血糖和糖化血红蛋白差异无统计学意义（均为P〉0．05），血糖低漂移组血糖标准差高于血糖高漂移组（t=5．4620，P〈0．05），而最大及平均血糖漂移幅度明显低于血糖高漂移组（t=5．9416和3．8281，均为P〈0．05）；（2）血糖高漂移组患者8-异-前列腺素F2α（8-iso-PGF2α）浓度明显高于血糖低漂移组[（57．56±3．86）ng／L和（34．21±3．82）ng／L]，差异有统计学意义（t=18．221，P=0．0000）；（3）血糖高漂移组多因素逐步回归分析显示，血糖标准差进入以8-iso-PGF2α为应变量的回归方程（β=1．959，P=0．013）。结论在老年2型糖尿病患者中，氧化应激与血糖漂移相关，提示血糖漂移可能为氧化应激的危险因素。Objective To investigate the correlation between glucose excursions and oxidative stress in the elderly type 2 diabetic patients. Methods Fifty five elderly type 2 diabetic patients （32 males and 23 females） were recruited. All the patients were submitted to continuous glucose monitoring system （CGMS） for three days. According to the result of CGMS monitoring ,the patients were divided into two groups： high glucose excursion group （30 cases） and low glucose excursion group （25 cases）. In high glucose excursion group, the therapy was adjusted for 4 weeks based on the CGMS monitoring. After the treatments, the specimens of blood were collected again to detect the related indexes. Results （1） There were no differences in age, blood pressure, fasting blood glucose and glycosylated hemoglobin between the two groups （all P〉0.05）. The stardard deviation of blood glucose was higher, and the maximun and average amplitude of glycemic excursion were significantly lower in high glucose excursion group than in low glucose excursion group （t = 5. 4620, 5. 9416,3. 8281 ,all P〈0.05）;（2） Compared with low glucose excursion group,plasma concentration of 8 -iso-PGF2α was obviously higher in high glucose excursion group [（57.56± 3.86）ng/L vs. （34.21±3.82） ng/L, t=18.221,P=0.0000）]. （3） Stepwise regression analysis showed that the standard deviation of blood glucose was involved in regression model （β= 1. 959, P = 0. 013）. Conclusions In elderly patients with type 2 diabetes mellitus, glucose excursion is related with oxidation stress, which suggests that the glucose excursion may be the risk factor for oxidation stress.

关 键 词：血糖 前列腺素F类 氧化性应激 

分 类 号：R686[医药卫生—骨科学]