腹型肥胖患者中医虚实证型脂联素表达差异及与肥胖特征相关性研究  

Differential expression of adiponectin in different Chinese medicine syndrome of central obesity and its correlation with obesity character

作　　者：李敏[1] 周丽波[1] 李修洋[1] 董柳[1] 仝小林[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中华中医药杂志》2009年第8期1027-1029,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然基金项目(No.30672580)

摘　　要：目的:观察腹型肥胖中医虚实证型脂联素表达差异及与肥胖特征性指标的相关性。方法:设立肥胖虚实证型组及正常对照组,对其相关代谢指标、脂联素表达进行检测,并探讨以上指标与肥胖特征的相关性。结果:腹型肥胖实证组和虚证组脂联素、空腹胰岛素(FINS)、腹内/腹壁脂肪比、胰岛素抵抗指数等指标差异有显著性意义(P<0.05或P<0.01),脂联素与甘油三酯、FINS、胰岛素抵抗指数存在负相关性(P<0.01)。结论:不同证型腹型肥胖的代谢特征有明显差异,这种代谢差异不仅来源于腰围的增加,更可能与腹腔内部脂肪堆积有关;脂肪因子脂联素的表达差异,提示虚证腹型肥胖有更明显的糖脂代谢异常和胰岛素抵抗的存在。Objective： to observe the differential expression of adiponectin in different Chinese medicine syndrome of central obesity and its correlation with obesity character. Methods： To establish xu and shi syndrome of central obesity groups, with normal group as control. The metabolic symptoms and adiponectin expression will be tested and be used to study their correlation with obesity character. Results： The level of adiponectin, ratio of VA/SA, and fast insulin（Fins）, HOMA-IR had significantly difference between the xu and shi groups （P〈0.05 or P〈0.01）. The adiponectin had negative correlation with triglyceride, Fins, HOMO-IR. Conclusions： The significant difference in biological base exited between different syndromes of visceral obesity, which came from not only the raise of waistline but also correlated with the fat in the abdominal cavity. The high level of adiponectin promote the existence of abnormity in metabolize of glucose and blood fat, insulin resistance.

关 键 词：腹型肥胖 虚证 实证 脂联素 

分 类 号：R259[医药卫生—中西医结合]