开郁清热方对自发肥胖型2型糖尿病大鼠糖脂代谢的影响  

Influence of Kaiyuqingre Formula on glycolipin metabolism in spontaneous obese T2DM rats

作　　者：甄仲[1] 常柏[1] 李敏[1] 李修洋[1] 于波[1] 刘文科[1] 仝小林[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中华中医药杂志》2009年第8期1056-1058,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国博士后科学基金资助项目(No.20070420510)

摘　　要：目的:探讨开郁清热方对自发肥胖型2型糖尿病(T2DM)大鼠糖脂代谢的作用及机制。方法:自发T2DM大鼠OLETF为研究对象,其同品系非糖尿病大鼠LETO为正常对照,给药12周,检测其糖脂代谢,并以正糖钳夹试验评价其胰岛素抵抗水平。结果:开郁清热中药可降低OLETF大鼠口服糖耐量血糖曲线下面积,改善正糖钳夹实验葡萄糖输注率,下调胆固醇、甘油三酯、游离脂肪酸水平。结论:开郁清热中药能有效调节自发T2DM大鼠糖脂代谢水平。Objective： To investigate the effects of Kaiyuqingre Formula （ KYQR ） on glycolipin metabolism in OLETF （Otsuka Long Evans Tokushima Fatty）. Methods： Forty OLETF and ten LETO as control were used. The rats were given KYQR by intragastric administration for 12 weeks. The rats＇ blood glucose and lipid were detected, and hyperinsulinemic-euglycemic clamping was used to show the degree of insulin resistant. Results： Glucose levels of plasma, TC, cholesterol and FFA in KYQR group were lower than those in control. Glucose infusion rates increased significantly in KYQR as compared with control. Conclusion： It suggested that Kaiyuqingre Formula can adjust glycolipin metabolism of OLETF rats.

关 键 词：开郁清热 2型糖尿病 OLETF 糖脂代谢 

分 类 号：R285.5[医药卫生—中药学]