6-氨基胡椒酸的合成工艺改进  

Improvement on synthetic technology of 6-amino piperonylic acid

作　　者：冯秀娥[1] 赵万一[1] 李青山[1] 

机构地区：[1]山西医科大学药学院药物化学教研室,太原030001

出　　处：《山西医科大学学报》2009年第8期711-712,共2页Journal of Shanxi Medical University

基　　金：国家"863"计划资助项目(2006AA09Z446);山西省归国留学人员科研基金资助项目(2008-51);山西省高等学校科技基金资助项目(200811011)

摘　　要：目的改进6-氨基胡椒酸的合成工艺。方法以胡椒酸为原料,经发烟硝酸硝化、铁粉或保险粉(Na2S2O4)还原,合成6-氨基胡椒酸。结果产物经HRMS,MS,1H-NMR,IR等分析手段进行了结构确证,总收率达到64%。结论本文首次以胡椒酸为原料合成了6-氨基胡椒酸。工艺路线合理可行,比传统的工艺路线易于控制,操作简单。Objective To improve the synthetic technology of 6-amino piperonylic acid. Methods The 6-amino piperonylic acid was prepared from piperonylic acid by nitration of piperonylic acid and reduction of 6-nitro piperonylic acid in the presence of iron powder or Na2S2O4. Results Products were characterized by HRMS, MS, ^1H-NMR, IR and other analytical methods. The overall yield was about 64%. Conclusion The 6-amino piperonylic acid is firstly successfully synthesized from piperonylic acid. And the designed technology provides a simple,reasonable and practicable procedure for the synthesis of 6-amino piperonylic acid. Moreover, It can be easily controlled compared with the former reported synthetic technology.

关 键 词：胡椒酸 6-硝基胡椒酸 6-氨基胡椒酸 硝化 还原 

分 类 号：TQ460.6[化学工程—制药化工]