卵蛋白诱发小鼠过敏性休克模型的建立  

Anaphylactic shock model induced by OVA in mice

作　　者：薛少华[1] 高彩荣[2] 

机构地区：[1]陕西省西安市公安局刑事侦查局技术处,710016 [2]山西医科大学法医病理学教研室,太原030001

出　　处：《刑事技术》2009年第4期7-8,共2页Forensic Science and Technology

摘　　要：目的建立卵蛋白致小鼠过敏性休克动物模型。方法将健康小鼠50只随机分为对照组和致敏组,致敏组小鼠于第1天腹腔注射致敏原,1周后加强注射一次,饲养3周后尾静脉注射致敏原诱发过敏性休克。结果致敏组小鼠均出现过敏性休克的典型临床表现及体征,肥大细胞脱颗粒百分数明显高于对照组。结论本实验成功地建立了小鼠过敏性休克动物模型,证明了小鼠对卵蛋白的高敏感性。Objective To establish anaphylactic shock model induced by Ovalbumin（OVA） in mice Method Fifty mice were divided into two groups： sensitized and control,the sensitized were immunized by intraperitoneal injection of allergen at first day and then duplicated after a week. Challenge was given by vena caudalis injection three weeks later. Results Symptoms of anaphylactic shock appeared in sensitized group. The percentage of mast eel] degranulation was increased in sensitized group significantly. Conclusions An animal model of anaphylactic shock was established successfully and it proved high sensitivity to OVA in mice.

关 键 词：过敏性休克 卵蛋白 小鼠 动物模型 

分 类 号：D919.4[医药卫生—法医学] Q959.837[政治法律—法学]