莪术醇对照品的主要有关物质分析  

Analysis of the related substance in reference substance of curcumol

作　　者：袁文娟 田颂九[2] 张启明[2] 李晓东[2] 

机构地区：[1]云南省食品药品检验所,昆明650011 [2]中国药品生物制品检定所,北京100050

出　　处：《药物分析杂志》2009年第8期1356-1358,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:鉴定化学对照品莪术醇中的主要有关物质。方法:采用LC-MS/MS联用法,以SHIMADZU VP-ODS柱(150mm×4.6mm,5μm)为色谱柱,乙腈-0.1%醋酸溶液(85∶15)为流动相,以APCI为离子源,采用一级、二级质谱全扫描方式,对莪术醇对照品中的有关物质进行色谱分离及质谱鉴定。结果:通过对分子质量、二级质谱碎片信息和液相保留时间三方面信息,与对照品比较,证明莪术醇对照品中的有关物质为异莪术烯醇。结论:为莪术醇对照品的标化和提纯提供了依据。Objective：To identify the related substance of curcumol.Methods：LC-MS/MS was adpopted to separated and identify he related substance of curcumol.The separation was performed on a C18 column and consist of 0.1%acetic acid -acetonitrle（85：15）,the mass spectrometer was operated on APCI and two scan modes including full scan MS and full scan MS/MS.The obtained mass spectra were analyzed for their fragmentation passways. Results：The obtained mother ions ,fragment ions and the retention time were adopted to identify the related substance of curcumol,which was isocurcumenol. Conclusion： It provides the basis for purification and standardized of curcumol reference substance .

关 键 词：LC—MS/MS 莪术醇对照品 有关物质 异莪术烯醇 

分 类 号：R917[医药卫生—药物分析学]