核受体辅活化子的家族新成员——PNRC  

PNRC:a new member of nuclear receptor coactivator family

作　　者：王越[1] 陈彬[1] 胡晨[2] 周度金[1] 

机构地区：[1]第三军医大学生物化学与分子生物学教研室 [2]第三军医大学学员旅8队,重庆400038

出　　处：《生命的化学》2009年第4期468-471,共4页Chemistry of Life

基　　金：国家自然科学基金(30672055);重庆市自然科学基金(CSTC.2006BB5352)资助

摘　　要：富含脯氨酸的核受体辅调节蛋白(proline-rich nuclear receptor coregulatory protein,PNRC)是一种普遍存在的核受体辅活化子,它能以配体依赖和非依赖方式与多种核受体相互作用并增强它们介导的转录激活。此外,它还能与Grb2和RNApol Ⅲ的RPC39亚基相互作用,参与生长因子/Ras信号通路和RNApol Ⅲ转录的调节。其在乳腺癌和癌旁正常组织中的表达差异使其有望成为治疗乳腺癌的新靶点。Proline-rich nuclear receptor coregulatory protein （PNRC） is a universal nuclear receptor coactivator, which can interact with many nuclear receptors in a ligand-dependent or a ligand- independent manner and enhance the transcriptional activation mediated by nuclear receptors. In addition, it may be involved in the regulation of growth factor/Ras signaling and RNA pol Ⅲ transcription through its interaction with Grb2 and the subunit RPC39 of RNA pol III. Its different expression in breast cancer and corresponding normal tissues indicates that it may be a new target in the therapy for breast cancer.

关 键 词：PNRC 核受体 辅活化子 

分 类 号：Q57[生物学—生物化学]