鱼类eIF2α激酶和PKZ  

EIF2α kinases and PKZ in fish

作　　者：吴初新[1] 林刚[1] 胡成钰[1] 

机构地区：[1]南昌大学生命科学与食品工程学院,南昌330031

出　　处：《生命的化学》2009年第4期529-533,共5页Chemistry of Life

基　　金：国家自然科学基金资助项目(No.30560116;30860218)资助

摘　　要：真核细胞翻译起始因子2α激酶是在进化中高度保守的丝氨酸/苏氨酸蛋白激酶,存在于哺乳类不同的组织和细胞中,通过调节翻译起始因子2α的活性参与机体内多种应激反应。eIF2α激酶主要包括HRI、PKR、PERK和GCN2等成员,其同源序列近年来在鱼类中也有相继克隆和报道。此外,新报道的一个鱼类干扰素系统中含Z-DNA结合域的蛋白激酶——PKZ,可能是一种新的eIF2α激酶。Eukaryotic initiation factor 2α （eIF2α） kinases belong to the highly conserved Ser/Thr protein kinases, distributed in different mammalian tissues and cells and mainly participated in a variety of emergency responses by regulating the activity of eIF2α. The eIF2α kinases mostly contain HRI, PKR, PERK and GCN2. Recently, several mammalian homolog of elF2α kinases in fish have also been reported in succession. In addition, a newly reported protein kinase with Z-DNA-binding domain in fish interferon system, PKZ, would be a new member of eIF2α kinases.

关 键 词：eIF2α激酶 PKZ 鱼类 

分 类 号：Q55[生物学—生物化学]