牛乳中分泌型IgA的合成机理及提高技术  

Secretion Mechanism and Improvement Technology of sIgA in Milk

作　　者：杨光[1] 王加启[1] 哈斯额尔敦[1] 赵圣国[1] 刘开朗[1] 卜登攀[1] 

机构地区：[1]中国农业科学院北京畜牧兽医研究所动物营养学国家重点实验室,北京100193

出　　处：《中国畜牧兽医》2009年第8期103-107,共5页China Animal Husbandry & Veterinary Medicine

基　　金：自然科学基金(30871837);"十一五"科技支撑计划(2006BAD04A10);动物营养学国家重点试验室自主研究课题(2004DA125184(青)0801)

摘　　要：分泌型IgA(sIgA)是介导黏膜免疫的主要免疫球蛋白,它的诸多理化特性保证了其黏膜免疫作用的发挥;牛奶中sIgA的合成与分泌是生物进化中黏膜免疫的附属产品,是为子代提供黏膜被动免疫的途径;作者综述了sIgA的功能及牛乳中sIgA的产生机理;并总结了通过免疫乳生产来提高乳中sIgA浓度的几种方法,为今后高滴度sIgA免疫乳生产提供一定的参考。sIgA is a primary immunoglobulin mediating mucosa immunity. Some physics and chemistry characteristics enable slgA to lead mucosa immunity. Synthesis and secretion of slgA in milk is accessorial production of mucosa immunity,which comes into being in evolution for offer passiveness immunity of mueosa for offspring. This article summarize function and synthesis mechanism of sIgA in milk. Some techniques to increase the content of slgA in milk are introduced. Thus some references were offered for production of immune milk with high-titer sIgA in future.

关 键 词：牛奶 SIGA 黏膜免疫 免疫乳 

分 类 号：Q51[生物学—生物化学]