皮肤划痕症患者血清超氧化物歧化酶、谷胱甘肽过氧化物酶及丙二醛的检测及意义  

Detection and evaluation of SOD,GSH-PX,MDA in serum of patients with dermatographism

作　　者：杨义成[1] 肖海珍[1] 刘镇平[1] 吴海斌[1] 石家宴[1] 

机构地区：[1]深圳市沙井人民医院皮肤性病科,广东深圳518104

出　　处：《岭南皮肤性病科杂志》2009年第4期216-217,共2页Southern China Journal of Dermato-Venereology

基　　金：深圳市宝安区科研项目(2007134)

摘　　要：目的:探讨皮肤划痕症患者氧化-抗氧化活性及意义。方法:40例皮肤划痕症患者检测血清超氧化物歧化酶(SOD),丙二醛(MDA),谷胱甘肽过氧化物酶(GSH-PX)含量,并与正常对照组相比。结果:病例组SOD,GSH-PX活性明显低于对照组(P<0.05),MDA高于对照组(P<0.05)。结论:在皮肤划痕症的发病机制中存在着氧化-抗氧化系统的失衡。Objective：To investigate the oxidative - antioxidative activity in serum of patients with dermatographism and its significance in clinical practice. Methods：Serum samples from 40 cases of dermatographism were collected for detection of SOD, MDA, GSH - PX contents, and compared with normal control group. Results：In the patient group, SOD, GSH - PX activity is lower （P 〈 0.05 ）, whereas MDA is higher than control group （ P 〈 0.05 ）. Conclusion： there is an imbalance in oxidative -antioxidative activity, which may be involved in the pathogenesis of dermatographism.

关 键 词：皮肤划痕症 超氧化物歧化酶 丙二醛 谷胱甘肽过氧化物酶 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]