侧脑室注射谷氨酸、MK-801及氯氨酮对大鼠吗啡戒断症状的影响  

Effect of intracerebroventricular injection of glutamic acid/MK-801/ketamine on morphine withdrawal syndrome in rats

作　　者：王红伟[1] 闫君宝[1] 王莹[2] 

机构地区：[1]河南科技大学医学院生理学教研室,河南洛阳471003 [2]西安交通大学医学院生理学与病理生理学系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2009年第4期419-421,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No .30500411)~~

摘　　要：目的研究中枢N-甲基-D-天冬氨酸受体(NMDA)系统的功能变化与吗啡依赖大鼠戒断症状的关系。方法建立吗啡依赖大鼠模型,纳洛酮催瘾后,分别侧脑室注射谷氨酸、MK-801、氯氨酮,观察其对大鼠戒断症状的影响。结果谷氨酸使大鼠咬牙、湿狗样抖动、扭体、添阴茎、体重减轻等项体征的评分显著增高,而MK-801及氯氨酮则相反。结论中枢NMDA系统的功能变化可显著影响吗啡依赖大鼠的戒断症状。本研究为用非阿片类药物治疗阿片耐受和成瘾提供了实验依据。Objective To study the relation between the level of central N-methyl-D-aspartate （NMDA） receptor system and the degree of morphine withdrawal syndrome in rats. Methods We established the morphine-dependence model in rats, stimulated addiction by naloxone after intracerebroventricular injection of glutamic acid/ketamine/MK-801, and then observed the effects on rats＇ morphine withdrawal syndrome. Results Glutamic acid significantly raised the behavior scores of teeth chattering, wet shakes, writhing, penis licking and weight loss, while ketamine and MK-801 decreased the scores. Conclusion Changes of central NMDA system obviously affect morphine withdrawal syndrome in rats, which may be useful laboratory evidence in selecting new no-opiod therapeutic medicine for morphine resistance and addiction.

关 键 词：谷氨酸 MK-801 氯氨酮 吗啡戒断症状 大鼠 

分 类 号：R338[医药卫生—人体生理学]