血管紧张素1-7抑制剂对糖代谢的影响  

Effect of Angiotensin-1-7 Inhibitor on Glycometabolism

作　　者：史婷婷[1] 马亚红[2] 杨金奎[1] 

机构地区：[1]首都医科大学附属北京同仁医院内分泌科 [2]北京普仁医院内分泌科

出　　处：《首都医科大学学报》2009年第4期455-458,共4页Journal of Capital Medical University

基　　金：国家自然科学基金(30671001)资助项目~~

摘　　要：目的研究血管紧张素1-7Ang(1-7)的抑制剂A779对胰岛功能及其他代谢指标的影响从而为研究Ang(1-7)在糖尿病及其合并症中的作用提供新的思路。方法对c57bl/6小鼠置入皮下泵持续给予A779干预,干预结束后行腹腔糖耐量试验、胰岛素耐量试验及胰岛素水平测定评价干预对糖代谢的影响,并测定血压、血脂及血管紧张素Ⅱ的水平,评价干预对其他代谢指标的影响。结果A779干预组的空腹胰岛素水平明显高于对照组,差异有统计学意义;胰岛素抵抗指数和胰岛素分泌指数明显高于对照组,差异有统计学意义。结论A779对糖耐量及胰岛素基础分泌产生负面影响,提示Ang(1-7)可能对胰岛功能具有保护作用。Objective To study the role of angiotensin 1-7 inhibitor A779 on glycometabolism and other metabolic indexes to explore a new way in curing diabetes and its complications. Methods Received a A779 was continuously infused to c57bl/s mice by subcutaneous implantation of an osmotic minipump. Glucose-tolerance tests, insulin-tolerance tests and determination of fasting plasma insulin were performed to evaluate glyeometablism. Level of blood triglyeeride, cholesterol and angiotensin II were assayed. Results Compared with the control group, A779 group mice displayed an impairment of glucose tolerance and an increase of fast insulin secretion. HOMA index of A779 group was increased. Conclusion A779 can affect glucose tolerance and insulin secrection, which suggest that angiotensin 1-7 may have a protective effect on the islet function.

关 键 词：血管紧张素转化酶2 血管紧张素1-7 A779 胰岛功能 

分 类 号：R31[医药卫生—基础医学] R58