Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone  

作　　者：ZHAI YingLei DENG LianDong LIN XiaoNa XIAO Li JIN FengMin DONG AnJie 

机构地区：[1]School of Chemical Engineering and Technology, Tianjin University, 'l-ianjin 300072, China

出　　处：《Chinese Science Bulletin》2009年第17期2918-2924,共7页

基　　金：Supported by the Key Project of Tianjin Municipal Natural Science Foundation (Grant No. 08JCZDJC17200);Tianjin Municipal Natural Science Foundation (Grant No. 08JCYBJC01800);National Natural Science Foundation of China (Grant No. 30672554)

摘　　要：Methoxy poly(ethylene oxide)-b-poly(ethyl cyanoacrylate) (mPEG-b-PECA), amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly(ethylene glycol) as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1H-NMR and FTIR. The results indicate that the structure of mPEG-b-PECA is well controlled with narrow molecular weight distribution. The dexamethasone (DXM)-loaded mPEG-b-PECA nanoparticles (NPs) were prepared by the nanoprecipitation technique and characterized by LPSA, 1H-NMR and TEM. The DXM-loaded mPEG-b-PECA NPs are of spherical shape with the size of less than 100 nm. The drug-loaded amount (DL) and encapsulation efficiency (EE) of DXM-loaded NPs were investigated by HPLC. The results show that DXM can be effectively incorporated into mPEG-b-PECA NPs, which provides a potential delivery system for DXM and other hydrophobic drugs.Methoxy poly（ethylene oxide）-b-poly（ethyl cyanoacrylate） （mPEG-b-PECA）, amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly（ethylene glycol） as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1H-NMR and FTIR. The results indicate that the structure of mPEG-b-PECA is well controlled with narrow molecular weight distribution. The dexamethasone （DXM）-loaded mPEG-b-PECA nanoparticles （NPs） were prepared by the nanoprecipitation technique and characterized by LPSA, 1H-NMR and TEM. The DXM-loaded mPEG-b-PECA NPs are of spherical shape with the size of less than 100 nm. The drug-loaded amount （DL） and encapsulation efficiency （EE） of DXM-loaded NPs were investigated by HPLC. The results show that DXM can be effectively incorporated into mPEG-b-PECA NPs, which provides a potential delivery system for DXM and other hydrophobic drugs.

关 键 词：甲氧基聚乙二醇 两亲嵌段共聚物 MPEG 地塞米松 纳米粒子 运载工具 丙烯酸酯 氰基丙烯酸乙酯 

分 类 号：TQ433.436[化学工程] O623.413[理学—有机化学]