阿托伐他汀治疗对老年冠心病患者冠脉血流储备影响的临床观察  

Effect of atorvastatin on coronary flow reserve in olderly patients with coronary heart disease

作　　者：王敏莲[1] 黄甦[2] 

机构地区：[1]武汉大学人民医院,湖北武汉430060 [2]武汉大学校医院,湖北武汉430071

出　　处：《中国医院药学杂志》2009年第16期1375-1377,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察老年冠心病(ECHD)患者冠状动脉血流储备(CFR)的变化及阿托伐他汀治疗后的影响。方法:应用彩色多普勒超声仪检测30例ECHD患者及35例健康志愿者中CFR,化学发光法测定2组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血浆内皮素-1(ET-1),且对治疗前后上述各项指标进行比较。结果:ECHD患者治疗前的TC、LDL-C及ET-1水平显著高于对照组(P<0.01),CFR低于对照组(P<0.01);经阿托伐他汀治疗8个月后,TC、LDL-C及ET-1水平均明显降低(P<0.05),而CFR明显升高(P<0.05)。结论:阿托伐他汀治疗可有效降低ECHD患者TC、LDL-C及ET-1水平,从而改善患者的CFR。OBJECTIVE To investigate the change of coronary flow reserve （CFR） in elderly patients with coronary heart disease （ECHD） and the effect on CFR treated with atorvastatin. METHODS CFR was detected in 30 ECHD patients and 35 healthy controls by color Doppler. And the total cholesterol （TC）, low-density lipoprotein cholesterol （LDLC）, triglyceride （TG） and endothelin 1 （ET-1） were detected by chemiluminescence. Compared the level of TC,LDL-C,TG and ET 1 and the change of CFR between pre-and post therapy with atorvastatin. RESULTS The level of TC, LDL-C and ET-1 in treatment groups was higher than in the healthy groups（P〈0. 01 ） and the CFR in the treatment groups was lower than in the healthy groups（P〈0. 01 ）. The level of TC, LDI/C and ET-1 significantly decreased（P〈0. 05） and the CFR significantly inereased（P 〈0. 05） in 8 months treated with atorvastatin. CONCLUSION The level of TC, LDDC of ECHD may be effectively decreased by treading with atorvastatin, and the CFR of ECHD could be improved.

关 键 词：阿托伐他汀 冠心病 冠脉血流储备 

分 类 号：R972[医药卫生—药品]