牛珀至宝丹对老年记忆减退大鼠脑内EGF阳性神经元的影响  

Influence of NPZBD on EGF Positive neurons in aged hypomnesia rat's brain

作　　者：谢斌[1] 严小军[1] 兰杨[1] 张紫蓬[1] 汪建民[1] 

机构地区：[1]江西中医学院,南昌330006

出　　处：《江西中医学院学报》2009年第4期65-67,共3页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：江西省教育厅科技项目(GJJ08323;赣教技字[2007]243号)

摘　　要：目的:研究牛珀至宝丹对老年记忆减退大鼠的脑尾壳核及皮质区EGF阳性神经元的影响。方法:以Morris水迷宫将老年大鼠(24月龄)筛选为记忆正常组、记忆减退组和牛珀治疗组,免疫组化检测尾壳核及皮质区EGF阳性神经元数量的变化。结果:牛珀治疗组老年大鼠学习记忆能力明显提高,其脑内尾壳核及皮质区EGF阳性神经元数量明显增加,与记忆减退组比较,有显著性差异(P<0.05)。结论:老年记忆减退大鼠学习记忆能力显著提高可能与牛珀至宝丹增加脑尾壳核及皮质区EGF阳性神经元的数量有关。Objective ：To study the influence of NPZBD on EGF positive neurons in Caudate putamen and cortex of aged hypomnesia rats. Methods：We randomly divided the aged rats into normal memory group, hypomnesia group and NPZBD treatment group with Morris water maze and detected changes of EGF Positive neurons in Caudate putamen and cortex with immunohistochemistry. Result ：The ability of learning and memory in aged hypomnesia rats in NPZBD treatment group was improved than the rats in hypomnesia group ; EGF positive neurons in Caudate putamen and cortex of aged hypomnesia rats in NPZBD treatment group was significant increased than the rats in hypomnesia group （P 〈0.05 ）. Conclusion：The ability of learning and memory in aged hypomnesia rats increased maybe connected with NPZBD increased EGF positive neurons in Caudate putamen and cortex of aged hypomnesia rats.

关 键 词：牛珀至宝丹 老年记忆减退 EGF 

分 类 号：R285.5[医药卫生—中药学]