TNFa-308基因启动子多态性与新疆维吾尔族人乙型肝炎易感性的相关性研究  

Study on the relationship between the genetic polymorphisms of TNFa Promoter and susceptibility of viral hepatitis B in XinJiang Uigur Population

作　　者：聂歆赢[1] 褚志华[2] 田世坤[2] 聂艳芳[2] 

机构地区：[1]石河子经济技术开发区医院 [2]石河子大学医学院,新疆石河子832000

出　　处：《现代生物医学进展》2009年第14期2655-2656,2696,共3页Progress in Modern Biomedicine

摘　　要：目的:研究TNF-a基因单核苷酸多态性(SNP)308G-A位点与新疆地区维吾尔族人乙型肝炎之间的关系。方法:以聚合酶链式反应--限制性内切酶长度多态性(PCR-RFLP)技术,对120例乙肝患者和120例正常对照者TNF-a基因SNP308多态性位点进行基因分型。结果:SNP308多态性位点G/G基因型和G/A基因型频率在病例组为77%和23%,正常对照组为88%和12%,2组基因型和等位基因频率分布差异有显著性(p<0.05)。结论:TNF-a基因启动子308多态性位点与新疆维吾尔族人乙肝有明显相关性。Objective： To investigate the correlation between single nucleotide polymorphisms （SNP308） of TNFa gene and viral hepatitis B in XinJiang Uigur Population. Method： A 1：1 Matched Case-control Study was conducted with 120 cases of viral hepatitis B and 120 population-based controls. TNFa gene polymorphisms genotypes were detected by PCR-RFLP. Result： The distribution of G/G and G/A genotype of the the TNFa at position -308 were 88%and 12% in hepatitis B patients,whereas 77% and 23% in the controls. The frequencies of alleles and genotypes of TNFa at position-308 in hepatitis B patients were significantly different from those of the controls （p〈0.05）. Conclusion： The results suggest that the TNFa308 gene were associated with viral hepatitis B in XinJiang Uigur Population.

关 键 词：肿瘤坏死因子Α 乙型肝炎 启动子 

分 类 号：R512.62[医药卫生—内科学] Q78[医药卫生—临床医学]