α7烟碱型乙酰胆碱受体与炎症调节  

α7 Nicotinic Acetylcholine Receptor and Inflammation Regulation

作　　者：周国武[1] 王雪琦[2] 田野苹[1] 

机构地区：[1]第二军医大学免疫学教研室,上海200433 [2]第二军医大学神经生物学教研室,上海200433

出　　处：《现代生物医学进展》2009年第14期2794-2797,共4页Progress in Modern Biomedicine

摘　　要：由促炎因子介导的炎症反应是机体对感染和损伤的一种防御机制。适量的促炎因子有利于激活免疫系统清除病原体,并可促进组织修复;而过量产生的促炎因子则可造成组织损伤,因此维持炎症反应的平衡十分重要。以往认为体液机制是炎症反应的唯一调节因素,新近发现的胆碱能神经抗炎通路对炎症反应的调节越来越受到人们的重视,而α7烟碱型乙酰胆碱受体(α7nAChR)是介导神经抗炎通路的关键分子。本文主要介绍α7nAChR的结构、分布及其介导的抗炎作用机制,并对α7nAChR激动剂及其临床应用研究和尚待解决的问题予以综述。Inflammatory reaction mediated by pro-inflammatory cytokines is a protective mechanism of organism against infection and injury. Appropriate production of pro-inflammatory cytokines is favorable to counteracting the invasion of pathogens and promoting tissue restoration, but excessive pro-inflammatory cytokines lead to tissue damages. Therefore, it is crucial to maintain the equipoise of inflammatory reactions. Humor mechanism had been thought to be the single anti-inflammation pathway until the cholinergic anti-inflammatory pathway （CAP） was demonstrated in recent years. Numerous studies indicate that the α7 nicotinic acetylcholine receptor （α7nAChR） is the key member in CAP. It will be introduced that the structure, distribution and anti-inflammatory effects of α7nAChR as well as its agonists and clinical application investigations in this review.

关 键 词：α7nAChR 抗炎作用 促炎症细胞因子 激动剂 

分 类 号：R392[医药卫生—免疫学] R338[医药卫生—基础医学]