羟乙桂胺乳膏离子导入透皮吸收的HPLC分析  

Analyzing transdermal iontophoretic delivery of emuliso idrocilamide by HPLC

作　　者：杨永革[1] 张梅[1] 靳颖华[1] 许景峰[1] 崔艳 

机构地区：[1]北京军区总医院药剂科

出　　处：《中国药学杂志》1998年第7期426-428,共3页Chinese Pharmaceutical Journal

摘　　要：目的：通过利用ＨＰＬＣ监测羟乙桂胺乳膏离子导入与直接外敷在家兔的透皮吸收过程，为临床经皮给药途径的研究提供参考。方法：家兔背部脱毛后，一组离子导入负极给药；一组直接外敷给药，于给药前后各时间兔耳缘静脉采血１．５ｍｌ，预处理后ＨＰＬＣ检测其血药浓度。结果：药时曲线符合二室模型，离子导入组与直接外敷组ｃｍａｘ和ｔｍａｘ均有显著性差异（Ｐ＜０．０５），分别为２．５７８ｍｇ·ｍｌ－１，１．３８８ｍｇ·ｍｌ－１和１．１４６，１．６０８ｈ。OBJECTIVE: To offer reference to clinical research on transdermal delivery system. METHODS: After the rabbit's back was shed, the reference group used the direct transdermal delivery system and the test group used iontophoresis. 1.5 ml venous blood was obtained before and after administration. After the pretreatment was done, the plasma concentration was determined by HPLC. RESULTS: The plasma concentration time curve fitted to the two compartment model. Comparision of iontophoresis with direct transdermal delivery system showed a remarkable difference (P<0.05). The main parameters (c max , t max ) were 2.578 mg·ml -1 , 1.388 mg·ml -1 , 1.146 h, 1.608 h respectively. CONCLUSION: Iontophoresis could remarkably enhance the transdermal delivery.

关 键 词：羟乙桂胺乳膏 离子导入 透皮吸收 HPLC 

分 类 号：R971.8[医药卫生—药品]