高压氧治疗新生儿缺氧缺血性脑病疗效观察  

作　　者：谢士军[1] 林泽鹏[1] 曾雪梅[1] 

机构地区：[1]广东省汕头市妇幼保健院,515041

出　　处：《浙江临床医学》2009年第8期796-797,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨高压氧治疗新生儿缺氧缺血性脑病（HIE）的临床疗效。方法将本院新生儿病房收治的足月HIE患儿128例随机分成高压氧治疗组（66例）和常规治疗组（62例）。高压氧治疗组在药物治疗基础上加高压氧治疗，常规治疗组只给予药物治疗。对上述两组患儿于生后3～12个月进行追踪随访，比较两组的后遗症发生率。结果高压氧治疗组有效率为90．9％，常规治疗组为74．2％，两组比较差异有统计学意义（P〈0．05）。高压氧治疗组出现后遗症9例（13．8％），常规治疗组后遗症17例（28．3％），两组比较差异有统计学意义（P〈0．05）。结论高压氧对HIE有着良好的辅助治疗作用，有利于新生儿脑功能恢复和减少后遗症的发生。Objective To evaluate the effects of hyperbaric oxygen （HBO） on infants with hypoxic - ischaemic encephalopathy （HIE）. Method 128 term newborns with HIE were randomly divided into two groups： the HBO group （n = 66 ） and the conventioal therapy group （ CON group, n = 62）. The infants of HBO group were treated both with medicine and with HBO, whereas the those of CON group were treated only with medicine. All infants were followed up for 3 - 12 months and the incidence rate of sequelae of infants were compared between the two groups. Results The effective power of the HBO group and the CON group were 90. 9% , 74. 2% , respectively and there was significant difference between the two groups （ P 〈 0. 05 ）. The incidence rate of sequelae of infants in the HBO group was less than that of the CON group （ 15.4% vs 28.3%, P 〈 0. 05 ）. Conclusion The HBO may be an adjunctive therapy for infants with HIE and could contribute to the recovery of neonatal cerebral function and decrease the incidence rate of sequelae of infants with HIE.

关 键 词：高压氧 缺氧缺血性脑病 新生儿 

分 类 号：R722.12[医药卫生—儿科] R459.6[医药卫生—临床医学]