双氯芬酸钠肠溶片质量考察  

Quality studies of diclofenac sodium enteric coated tablets

作　　者：谢云 薛大权 卢源峰 杨国江 赖淑武 

机构地区：[1]湖北省药检高等专科学校,武汉430064 [2]江汉油田中心医院,江汉433124

出　　处：《中国现代应用药学》1998年第3期42-43,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：利用RP-HPLC,以卡马西平(CZ)为内标,对国内3个厂家生产的双氯芬酸钠(D5)肠溶片进行了崩解度、释放度、含量测定的研究。结果表明:不同厂家的DS肠溶片释放度差异极为显著(P<0.01)、崩解度与释放度之间有较好的相关性(r=0.9103)。The disintegration, release rate and assay of diclofenac sodium enteric coated tablets produced by three factories(A,B,C) in our country were determined by RP - HPLC with internal standard carbamazepine.The results showed that the difference of the release rate of different factories was very significant ( P < 0.01), the correlation between their disintegration and release rate was good(r =0.9013).

关 键 词：双氯芬酸钠 肠溶片 崩解度 释放度 相关性 

分 类 号：R971.1[医药卫生—药品] R927.11[医药卫生—药学]