疏血通注射液对急性冠脉综合征血栓前状态的影响  

The shuxuetong therapy′s effect on the pre-thrombus state in acute coronary syndromes

作　　者：余琴[1,2] 李新[1,2] 欧阳迎春[1,2] 石娟[1,2] 

机构地区：[1]泸州医学院附属医院心内科,四川泸州646000 [2]泸州医学院附属医院胸心外科,四川泸州646000

出　　处：《四川医学》2009年第8期1251-1253,共3页Sichuan Medical Journal

摘　　要：目的观察疏血通注射液对急性冠脉综合征(ACS)血栓前状态的干预作用。方法采用随机对照方法将68例急性冠脉综合征患者随机分为两组,疏血通组(35例)静脉滴注疏血通注射液8ml,1次/d,共2周。对照组(33例)除不用疏血通外,其他用药与疏血通组相同。治疗前和治疗2周后测量两组血浆纤维蛋白原(Fig)、血管性血友病因子(vWF)、D-二聚体(D-D)、纤溶酶原激活剂抑制物(PAI)、血小板膜糖蛋白140(GMP-140)的含量。结果疏血通组和对照组在治疗前血浆PAI活性、Fig、D-二聚体(D-D)、vWF、GMP-140水平差异无统计学意义(P>0.05)。两组治疗前后比较治疗后血浆Fig、vWF、D-D、PAI、GMP-140的含量均低于治疗前(P<0.05或P<0.01)。疏血通组治疗后血浆Fig、vWF、D-D、PAI的含量低于对照组,差异有统计学意义(P<0.05);而血浆GMP-140含量低于对照组,差异无统计学意义(P>0.05)。结论疏血通注射液可改善急性冠脉综合征患者血栓前状态,预防血栓形成。Objective To investigate the Shuxuetong therapy＇ s effect on the Pre-thrombus State in acute coronary syn- dromes （ACS）. Methods 68 patients with ACS were divided randomly into Shuxuetong group （35 patients） （Shuxuetong 8 ml qd× 14 days ） and control group （33 patients）. Control group did not administrate Shuxuetong therapy, the other drugs were same as Shuxuetong therapy group. Plasma concentrations of fibrinogen （Fig）, plasma concentrations of yon Willebrand factor （vWF）, D-Dimer （D-D）.plasminogen activator inhibitor （PAI）.platelet membrane glucoprotein（GMP-140） level were measured in 2 group ACS patients before and 2 weeks after administration. Results Plasma Fig.PAI-1 .vWF.GMP-140 and D-D level before drug administration were not significantly different between 2 groups（P〉0. 05 ）. Compared with control group ,Plasma Fig.PAI-1. vWF and D-D level after drug administration in Shuxuetong group were significantly lower（P〈0.05）. Conclusion This study demonstrates Shuxuetong can improve the prethrombotic state in （ACS）.

关 键 词：急性冠脉综合征 疏血通注射液 血栓前状态 

分 类 号：R259[医药卫生—中西医结合]