重症多形红斑及中毒性表皮坏死松解症18例临床分析  

Analysis of 18 cases of major erythema multiforme and toxic epidermal necrolysis

作　　者：郑德勤[1] 

机构地区：[1]凉山州第一人民医院皮肤科,四川西昌615000

出　　处：《四川医学》2009年第8期1285-1286,共2页Sichuan Medical Journal

摘　　要：目的总结分析重症多形红斑及中毒生皮坏死松解症的临床资料、治疗及转归。方法回顾性分析18例药物所致的重症多形红斑及中毒性表皮坏死松解症患者的一般资料、临床表现、实验室及辅助检查、治疗及转归。结果致敏药物以别嘌和卡马西平多见。患者除有皮肤损害外,还伴有粘膜损害,60%的患者有肝、肾不同程度受累。18例患者均采用足量糖皮质激素治疗,6例患者联合大剂量静脉注射用人免疫球蛋白治疗。除1例患者因肾衰竭死亡外,其余患者治愈或好转。结论重视支持性治疗,及早采用足量糖皮质激素对促进皮损愈合、缩短病程有效,对病情难以控制的患者可早期应用大剂量静脉注射用人免疫球蛋白治疗。Objective Twelve cases of major erythema multiforme and sixcases toxic epidermal necrolyses from 2002 to 2008 were studied retrospectively. Methods Allpurinol and carbamazepine were the most common offending agents in these pa- tients（ 12/18）. Results Aside from skin lesions, mucous membrane was involved in all cases, and dysfunctions of liver or kidney were observed in 60% cases . Conclusion Adequate amounts of corticosteroids were used in all case and aggressive dosage of immunoglobulius were given intravenously to six patients. Seventeen cases were cured and one died from renal failure.

关 键 词：重症多形红斑 中毒性表皮坏死松解症 临床分析 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]