精制血府胶囊治疗冠心病心绞痛的临床研究  

Clinical Study of Purified Xuefu Capsule in Treating Angina Pectoris

作　　者：汪晓芳[1] 陈可远[1] 王伟[1] 史大卓[1] 周佩云[1] 陈可冀[1] 

机构地区：[1]中国中医研究院西苑医院,北京100091

出　　处：《中国中西医结合杂志》1998年第7期399-401,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家科委博士基金项目!(94 D 12 )

摘　　要：目的 :为观察精制血府胶囊对冠心病心绞痛的治疗作用。方法 :5 7例患者随机单盲分为精制血府胶囊组 (3 0例 ,常规西药加精制血府胶囊治疗 )与常规西药治疗组 (2 7例 ,单用西药治疗 )。结果 :精制血府胶囊组心绞痛总有效率为 93 3 % ,心电图总有效率为 63 3 % ,均优于常规西药治疗组 (分别为 66 7%、3 7 4% ,P <0 0 5 )。治疗后血浆内皮素 -1 (endothelin 1 ,ET 1 )浓度由 85 0 9± 3 7 5 6ng/L下降至 61 1 9± 4 0 2ng/L ,血清降钙素基因相关肽 (calci toningenerelatedpeptide,CGRP)浓度由 5 8 64± 1 9 3 0ng/L上升至 88 87± 2 0 41ng/L ,治疗前后ET -1及CGRP差值与常规西药治疗组比较有显著性差异 (P <0 0 1 )。结论 :加用精制血府胶囊治疗冠心病心绞痛比单用西药效果更好。Objective: To study the effect of purified Xuefu Capsule (PXFC)in treating angina pectoris (AP). Methods: Fifty seven patients with AP were randomly divided into two groups. Group A (30 cases) was treated with PXFC and western medicine, and group B(27 cases) with western medicine (isosorbide dinitrate, diltiazem or atenolol) alone. Results: The total effective rates and ECG ST T changes of AP were 93.3% and 63.3% respectively in group A. These results were all superior to those of group B (P<0 05). Moreover, in group A the level of plasma endothelin (ET 1) decreased from 85.09±37 56 ng/L to 61.19±4.02ng/L , and that of calcitonin gene related peptide (CGRP) increased from 58.64±19.30ng/L to 88.87±20.41ng/L . Comparing with group B, these changes were statistically different (P<0 01). Conclusions: The effects of adding PXFC on conventional treatment withwestern medicine were better than those of westem medicine.

关 键 词：精制血府胶囊 心绞痛 内皮素 降钙素 基因相关肽 

分 类 号：R259.414[医药卫生—中西医结合]