新型超声造影剂对肝纤维化-肝硬化定量诊断的研究  

Study of new type of an ultrasound contrast agent in quantitative diagnosis of hepatic fibrosis and cirrhosis

作　　者：庄静 胡建群[1] 王剑翔[1] 蔡晓峰[1] 

机构地区：[1]南京医科大学第一附属医院超声诊断科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2009年第8期1164-1166,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省社会发展计划(BS2006075)

摘　　要：目的:探讨新型超声造影剂对肝纤维化-肝硬化定量诊断的研究。方法:肝纤维化、肝硬化患者各20例,均经肝穿刺病理证实,正常对照组10例,无任何肝脏病史,采用实时灰阶超声造影,团注法注入声诺维(SonoVue),测定肝静脉到达时间(HVAT)及肝动脉到达时间(HAAT),两者相减得到肝动静脉渡越时间(HA-VTT)。结果:HA-VTT在正常对照组、肝纤维化组、肝硬化组间两两比较均有统计学意义(P<0.05),肝硬化组HA-VTT较正常对照组明显缩短(P<0.01)。结论:利用新型超声造影剂测量HA-VTT有望成为定量诊断肝纤维化、肝硬化的新方法。Objective：To investigate the significance of contrast-enhanced ultrasound in quantitative diagnosis of liver fibrosis and cirrhosis. Methods：Twenty cases of liver fibrosis and 20 cases of liver cirrhosis proven by biopsy were enrolled in this study while 10 cases without liver disease history served as controls. A real time gray-scale contrast enhanced ultrasound was performed with SonoVue bolus injection to determine hepatic artery to vein transit time （HA-VTT）. Results：There is a significant difference of the HA-VTT among the three groups （P 〈 0.05）. HA-VTT in hepatic cirrhosis group was shorter than controls （P 〈 0.01 ）. Conclusion： Determination of HA-VTT were considered to be a new diagnostic method in quantitative diagonosis of hepatic fibrosis and cirrhosis.

关 键 词：肝纤维化 肝硬化 超声造影剂 HA-VTT 

分 类 号：R445.1[医药卫生—影像医学与核医学]