非糖尿病患者糖化血红蛋白水平与颈动脉病变相关性  

HbA_1c level and carotid artery pathological changes in non-diabetic patients

作　　者：李斌儒[1] 张兰[1] 丁慧萍[1] 刘燕[2] 

机构地区：[1]兰州军区机关门诊部,甘肃兰州730000 [2]兰州军区兰州总医院,甘肃兰州730050

出　　处：《中华保健医学杂志》2009年第4期275-277,共3页Chinese Journal of Health Care and Medicine

摘　　要：目的探讨非糖尿病人群糖化血红蛋白(HbA1c)水平与颈动脉病变的相关性。方法选择心脏内科非糖尿病患者348例,按HbA1c水平分为A组(HbA1c<5%,n=109例)、B组(HbA1c5%～5.9%,n=152例)、C组(HbA1c≥6%,n=87例;颈动脉超声测定颈总动脉内膜中膜厚度(IMT),以IMT≥0.9mm或粥样斑块形成判定为颈动脉超声阳性,分析HbA1c水平与颈动脉超声阳性检出率的相关性。结果随着HbA1c的增高,颈动脉超声阳性的患者检出率有明显增加(A、B、C组分别为43.1%、56.6%、78.2%,P<0.05)。Logistic多元回归分析显示HbA1c水平的轻度升高,也与颈动脉超声阳性独立相关(P<0.05)。结论在非糖尿病人群中,HbA1c轻度升高也是颈动脉病变发生、发展的一个重要的独立危险因素。Objective To examine the relationship between HbA1c level and carotid artery pathological changes in non-diabetic patients. Methods 348 non-diabetic in heart medicine were enrolled. Aecording to HhA1c level, the patients were divided into,A group（HbA1c〈5%,n=109eases）,B group（HbA1c 5%-5.9%,n=152eases）and C group（HbA1c≥6%,n=87cases）,carotid intima-media thiekness （IMT）was determined by carotid ultrasound ,masculine of carotid ultrasound was difined as intima-media thiekness（IMT）of common carotid artery≥0.9 mm,or occurrence of carotid plaque. Results Compared with the carotid AS negative subjects,the carotid AS positive patients had significant higher HbA1c,fasting glucose,2h glucose,UA,LDL-C,HDL-C and systolic blood pressure level. With higher HbA1c was associated with more prevalence of carotid AS. Logistic regression analysis shows light hoisted HbA1c was an independent predictor of carotid AS. Conclusions HbA1c is an independent risk factor for carotid artery pathological changes and positively correlated with carotid artery pathological changes in non-diabetic patients.

关 键 词：糖化血红蛋白 颈动脉病变 危险因素 

分 类 号：R44[医药卫生—诊断学]