川芎嗪对犬肾保存的影响  

Effect of ligustrazine on canine kidney preservation

作　　者：陈刚[1] 张肖红[1] 陈实[1] 吴瑛 张红[1] 朱建国 马绪娴[1] 左利群 

机构地区：[1]同济医科大学附属同济医院器官移植研究所

出　　处：《中华器官移植杂志》1998年第3期162-163,共2页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金

摘　　要：通过犬自体肾移植模型研究了一定浓度的川芎嗪加入ＷＭＯ－１号液对犬肾保存效果的影响。结果表明，单纯ＷＭＯ－１号液保存７２小时和加川芎嗪保存７２小时的肾行自体移植均难存活；加川芎嗪保存４８小时组术后血肌酐的平均值低于单纯ＷＭＯ－１号液保存４８小时组，且血肌酐恢复正常的时间也较单纯ＷＭＯ－１号液组早（Ｐ＜０．０５），说明该实验浓度的川芎嗪不能延长肾保存时间，但有利于移植肾功能的早期恢复。The canine kidney autologous transplant model was used to investigate the effect of ligustrazine with a certain concentration added to WMO1 solution on kidney preservation. The results showed that the canine autologously transplanted kidneys were difficult to survive with 72h preservation of WMO-1 alone and WMO-1 plus ligustrazine. The mean serum creatine level after operation in 48 h ligustrazine preservation group was lower than in 48 h WMO-1 preservation group, and the recovery of serum creatine level in the former group was earlier than in the latter group (P<0.05). These results suggested that the ligustrazine concentration used could not prolong the preservation time of WMO-1 solution to kidney, but could be of benefit to the recovery of renal function in the early stage. 

关 键 词：组织保存 肾移植 自体移植 川芎嗪 

分 类 号：R277.592[医药卫生—中医学]