多次小睡潜伏时间试验在诊断嗜睡症的应用  

Application of multiple sleep latency test in disorders of excessive sleepiness

作　　者：肖毅[1,2] 黄席珍[1,2] 邹丁 吴全有 

机构地区：[1]中国医学科学院 [2]中国协和医科大学北京协和医院睡眠呼吸疾患诊疗中心

出　　处：《中华内科杂志》1998年第7期470-472,共3页Chinese Journal of Internal Medicine

摘　　要：目的多次小睡潜伏时间试验（ＭＳＬＴ）客观评价嗜睡严重程度、治疗效果及鉴别诊断。方法对１２例正常人、１７例发作性睡病及１２例阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）患者进行ＭＳＬＴ检查。结果正常对照平均ＭＳＬＴ为２０．１±６．７分；快速眼动睡眠（ＲＥＭ）０．１±０．３次。发作性睡病组平均ＭＳＬＴ３．１±１．９分（与正常组比较，Ｐ＜０．０１；与ＯＳＡＳ组比较，Ｐ＜０．０５）；ＲＥＭ睡眠次数３．４±１．４次（与正常组比较，Ｐ＜０．０１；与ＯＳＡＳ组比较，Ｐ＜０．０５）。ＯＳＡＳ组平均ＭＳＬＴ５．７±３．２分，ＲＥＭ睡眠次数１．７±１．４。Objective Excessive daytime sleep (EDS)is a common complaint of certain out patients; it has different causes and different degrees of severity. Multiple sleep latency test(MSLT) is used in the assessment and diagnosis of disorders of excessive somnolence and to evaluate daytime sleepiness in relation to various therapeutic manipulations. Methods 12 control, 17 narcoleptic and 12 obstructive sleep apnea syndrome (OSAS) subjects were examined with MSLT, which consisted of 30 minute. Opportunities to sleep offered at 9∶00, 11∶00, 13∶00, 15∶00, 17∶00 o'clock. Results The mean MSLT time in the narcoleptic group was 3.1±1.9 min, as compared with 20.1±6.7 min ( P <0.01) in the control group , and 5.7±3.2 min ( P <0.05) in the OSAS group. The mean number of REM sleep episodes in the narcoleptic groups was 3.4±1.4, as compared with 0.1 ±0.3 ( P <0.01) in the control group, and 1.7±1.4 in the OSAS group. Conclusion The MSLT can demonstrate pathological sleepiness in narcoleptics and OSAS and that multiple measurements of sleep latency can diffe rentiate narcoleptics from control subjects.

关 键 词：嗜睡症 诊断 多次小睡 潜伏时间 

分 类 号：R563.904[医药卫生—呼吸系统]