^(60)钴-γ射线对赤芍药材有效成分的影响  

Effect of ^(60)Co-γ-Rays on the Active Component of Radix Paeoniae Rubra

作　　者：吴冬梅[1] 刘卫红[2] 张娜娜[2] 张振巍[3] 

机构地区：[1]河南省中医院,郑州市450002 [2]河南中医学院第一附属医院,郑州市450000 [3]甘肃中医学院,兰州市730030

出　　处：《中国药房》2009年第24期1894-1896,共3页China Pharmacy

摘　　要：目的:研究赤芍药材经60钴-γ射线辐照前、后有效成分的变化。方法:采用高效液相色谱法测定受辐照前、后赤芍药材中芍药苷的含量,色谱柱为Spherigel ODS C18(150mm×4.6mm,5μm),流动相为甲醇-水(梯度洗脱),检测波长为260.5nm。结果:赤芍药材经60钴-γ射线辐照后芍药苷的含量降低了近20%。结论:在处理含赤芍药材的中药制剂时应考虑到辐照对主成分的影响。OBJECTIVE： To study the change of the active components in Radix Paeoniae Rubra before and after the radiation of 60Co-γ- rays. METHODS： The content of paeoniflorin in Radix Paeoniae Rubra before and after the radiation of 60Co-γ- rays was determined by HPLC on Spherigel ODS C18（150 mm × 4.6 mm, 5 μm） chromatographic column. The mobile phase consisted of methanol-water （gradient elution） with the detection wavelength set at 260.5 nm. RESULTS： The content of paeoniflorin in Radix Paeoniae Rubra dropped by nearly 20% after the radiation of 60Co-γ- rays. CONCLUSION： The effect of the radiation of 60Co - γ - rays on the active component should be taken into consideration in treating the Chinese drugs preparation of Radix Paeoniae Rubra.

关 键 词：赤芍 60钴-γ射线 芍药苷 含量 影响 

分 类 号：R284.1[医药卫生—中药学] R927[医药卫生—中医学]