Nogo在中枢神经损伤再生中的作用机制  

Mechanism of Nogo during regenerating in the lesioned central nervous system

作　　者：黄海珍[1] 桑锋[1] 王玉霞[1] 姚静[1] 鲁亚平[1] 

机构地区：[1]安徽师范大学生命科学学院,芜湖241000

出　　处：《生物学杂志》2009年第4期61-64,共4页Journal of Biology

摘　　要：Nogo是中枢神经系统(CNS)少突胶质细胞分泌的一种髓磷脂蛋白,它的主要功能是抑制损伤后轴突的再生,它含有两个完全独立的具有抑制活性的结构域:位于细胞内的amino-Nogo和位于细胞表面的Nogo-66。Nogo-66是通过与受体复合体NgR/p75/Lingo-l结合,触发Rho信号通路来发挥作用。Nogo及其信号转导机制日益成为CNS损伤再生的研究热点,就Nogo在CNS损伤再生中的作用机制作一综述。Nogo is a myelin-associated protein that has been shown to inhibit axonal sprouting after lesions to the central nervous system （CNS）. Two distinct inhibitory regions of Nogo-A have been identified： amino-Nogo and Nogo-66. Nogo-A and its receptors, especially Nogo-66 receptor （NgR）, p75 neurotrophin receptor （p75NTR）, and LINGO-1 increasingly became the hot topic in the study of lesioned CNS. The present research on mechanism of Nogo in the lesioned CNS was simply introduced in this review.

关 键 词：NOGO NOGO受体 抑制因子 神经再生 

分 类 号：Q954.2[生物学—动物学]