腹膜透析患者心脏瓣膜钙化的临床研究  

Cardiac valve calcification in patients undergoing peritoneal dialysis

作　　者：高峰[1] 王宝仁[1] 贺晓[1] 高德[1] 吴琼[1] 

机构地区：[1]武警辽宁总队大连医院肾内科,大连116013

出　　处：《武警医学》2009年第8期707-709,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨持续性非卧床腹膜透析(Continuous ambulapory peritoneal dialysis,CAPD)患者心脏瓣膜钙化的危险因素,降低CAPD患者心血管疾病发生率。方法将54例CAPD患者根据透析时间长短及心脏瓣膜钙化程度分组,观察心脏瓣膜钙化与血钙、血磷、白蛋白等各生化指标的关系。结果腹膜透析患者中存在不同程度心脏瓣膜钙化,随着透析时间的延长,瓣膜钙化率增加(P<0.01);钙化组血磷、钙磷乘积、甲状旁腺激素较无钙化组显著增高,而白蛋白较无钙化组显著降低(P<0.05或P<0.01)。结论腹膜透析患者心脏瓣膜钙化程度与营养状态及透析时间密切相关,患者高磷血症及钙磷乘积升高是心脏瓣膜钙化的重要危险因素。Objective To study the relevant factors of cardiac valve calcification in patients undergoing peritoneal dialysis and to reduce their incidence of cardiovascular diseases. Methods The peritoneal dialysis patients were divided into different groups ac- cording the time of undergoing dialysis and the different level of cardiac valve calcification. The relationship between cardiac valve cal- cification and calcium, phosphonium, albumin, was analyzed. Results Cardiac valve calcification with different level existed in dialy- sis patients , The longer peritoneal dialysis time, the more severer cardiac valve calcification（P 〈 0.01 ）. Patients with valve calcifica- tion had higher serum phosphate level , calcium - phosphorus product, PTH and lower serum albumin than those without valve calcifi- cation （ P 〈 O. 05 or 0.01 ）. Conclusions Cardiac valve calcification is correlated with the nutritional status and the peritoneal dialysis time in patients undergoing peritoneal dialysis. The higher serum phosphate level and calcium - phosphorus product is correlated with cardiac valve calcification closely. They are the important dangerous factors of cardiac valve calcification.

关 键 词：腹膜透析 心脏瓣膜钙化 钙磷代谢 钙磷乘积 

分 类 号：R459.5[医药卫生—治疗学] R542.5[医药卫生—临床医学]