鸭血烯酸对艾氏癌生长的抑制作用  

Inhibition Effects of Duck Blood Alkenoic Acid (DBAA) on Growth of Ehrlich Tumor

作　　者：杨树青[1] 沈林娣 王世平[1] 陈燃[1] 毛裕民[1] 

机构地区：[1]复旦大学 [2]长江生化制药厂

出　　处：《复旦学报（自然科学版）》1998年第4期505-508,共4页Journal of Fudan University：Natural Science

基　　金：上海市科学技术委员会上海长江生化制药厂资助

摘　　要：鸭血烯酸是由鸭血清中提取的不饱和脂肪酸．在体外实验中具有使艾氏腹水癌细胞膨胀失活的作用．用于治疗艾氏癌患鼠，可抑制其腹水癌和实体瘤的生长．与环磷酰胺（CPA）或氟脲嘧啶（SFU）相比，鸭血烯酸的毒性较低，疗效较高，约20％～40％被治愈的患鼠，可长期存活．The duck blood alkenoic acid (DBAA) is an unsatrupted fatty acid extracting from the duck serum. In vitro, it damages the Ehrlich ascites tumor cells. In vivo, the growth of both ascites tumor and solid tumor was inhibited by DBAA. The DBAA has lower toxicity and higher curative effect compared with CPA (cyclophosphamid) and SFU (5-fluorine uracil). About 20% ~ 40% mice of Ehrlich ascites tumor-bearing were cured from eliminating tumor with a long survival time.

关 键 词：鸭血烯酸 不饱和脂肪酸 艾氏腹水癌 抗癌药物 

分 类 号：R979.19[医药卫生—药品] R730.5[医药卫生—药学]