甲基强的松龙对深低温脑缺血再灌注大鼠脑组织S-100β蛋白表达的影响  

Influence of methylprednisolone on the expression of S-100 beta protein after deep hypothermia cerebral ischemia reperfusion in rats

作　　者：章云峰[1] 徐康康[1] 彭卫[2] 莫绪明[2] 

机构地区：[1]南京医科大学附属南京儿童医院药剂科,江苏南京210008 [2]南京医科大学附属南京儿童医院心胸外科,江苏南京210008

出　　处：《中国生化药物杂志》2009年第4期261-263,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：南京市医学科技发展项目基金(YKK07051)

摘　　要：目的观察甲基强的松龙(MP)对深低温脑缺血再灌注大鼠脑组织S-100β蛋白表达的影响。方法将SD大鼠随机分为假手术组、模型组和MP组,应用SABC技术检测脑组织S-100β蛋白表达。结果假手术组脑组织S-100β蛋白呈基础水平表达;MP组S-100β蛋白表达量与模型组比较显著降低。结论MP可能通过抑制S-100β的过量表达,对深低温缺血再灌注脑损害发挥保护作用。Purpose To observe the effect of methylprednisolone on the expression of S-100 beta protein after deep hypothermia cerebral ischemia reperfusion in rats. Methods SD rats were divided randomly into three groups： sham group, methylprednisolone group and model group. The expressions of S-100 beta protein were detected by SABC. Results The expressions of S-100 beta protein were at basal level in sham group, while were significantly lower in methylprednisolone group than that in model group. Conclusion Methylprednisolone played a protective role in rats cerebral injury after deep hypothermia cerebral ischemia reperfusion through inhibiting the excessive expression of S-100 beta protein.

关 键 词：甲基强的松龙 脑损害 缺血再灌注 S-100Β蛋白 

分 类 号：R962[医药卫生—药理学]