剀西莱联合胸腺肽治疗慢性乙型肝炎疗效观察  

Analysis of curative effects of tiopronin and thymopolypeptide in treating chronic hepatitis B

作　　者：马长林 韩怡 

机构地区：[1]阜阳肿瘤医院消化内科,安徽阜阳236018

出　　处：《现代医药卫生》2009年第18期2742-2743,共2页Journal of Modern Medicine & Health

摘　　要：目的:观察凯西莱联合胸腺肽治疗慢性乙型肝炎的疗效。方法:将我院收治的83例慢性乙型肝炎患者随机分为治疗组43例和对照组40例。两组均不用其他褪黄、降酶及抗病毒药物。在基础治疗相同的基础上,治疗组给予静脉滴注凯西莱200 mg/d+胸腺肽20 mg/d;对照组则给予静脉滴注还原型谷胱甘肽1 200 mg/d,两组疗程均为4周。观察治疗前后血清转氨酶(ALT、AST)、白蛋白(Alb)、球蛋白(Glb)、胆红素(TBil、DBil)变化。结果:两组肝功能、临床症状均明显改善,两组ALT、AST、Alb、Glb、TBil较治疗前均下降,差异有非常显著性(P<0.01),但组间比较差异无显著性(P>0.05)。两组总有效率分别为95.35%和85%,差异有显著性(P<0.01)。结论:凯西莱注射液联合胸腺肽治疗慢性乙型肝炎不但疗效确切,而且安全可靠。Objective ：To observe the clinical curative effects of the combinations of tiopronin and thymopolypeptide in the treatment of chronic hepatitis B.Methods：83 patients with chronic viral hepatitis B were randomly divided into therapeutic group（n=43） and control group （n=40）.Tiopmnin for injection was given to therapeutic group once daily by intravenous drip in dosage of 200mg with 5% glucose solution 250mL and thymopolypeptide for injection was given to therapeutic groups once daily by intravenous drip in dosage of 20rag with 10% glucose solution 250 ml. While the control group was treated with TAD for injection（120Omg/d）.All the patients were treated for 4 weeks.The levels of ALT,AST,Alb,Glb and TBil were monitored before and after treatment.Results：The liver functions in two groups were both improved remarkably.The levels of ALT, AST, Alb, Glb ,TBil decreased obviously after the treatment （P〈0.01）. There were no difference between the two groups.The total effective rate was 95.35% and 85% respectively.There was significant dfferenee between the two groups.Conelusion：Tiopronin and thymopolypeptide for injection not only have remarkable effects on chronic hepatitis B,but also have no poisonous and side effect.

关 键 词：凯西莱 胸腺肽 慢性乙型肝炎 还原型谷胱甘肽 

分 类 号：R5[医药卫生—内科学]