轻度认知功能损害的BOLD-fMRI研究进展  

Progress of BOLD-fMRI study in mild cognitive impairment

作　　者：金光暐[1] 李坤成[1] 

机构地区：[1]首都医科大学宣武医院放射科,神经变性病教育部重点实验室,北京100053

出　　处：《中国医学影像技术》2009年第8期1515-1517,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(30770620)

摘　　要：对轻度认知功能损害(MCI)患者执行记忆任务时的BOLD-fMRI研究已揭示了人类记忆损害时记忆环路功能的异常。应用BOLD-fMRI对MCI内颞叶记忆系统功能激活异常与脑功能连接的关系也在进一步研究中。本文对MCI的BOLD-fMRI研究进展进行综述。BOLD-fMRI studies of mild cognitive impairment （MCI） have revealed functional abnormalities in memory circuit in humans suffering from memory disorders during memory task performance. Recently BOLD-fMRI data in MCI is beginning to reveal the relationship between abnormalities of functional activity in the medial temporal lobe memory system and in functionally connected brain regions. The progress of BOLD-fMRI study in MCI was reviewed in this article.

关 键 词：阿尔兹海默病 轻度认知功能损害 海马 颞叶 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]