VEGF-C与非小细胞肺癌淋巴管密度及淋巴结转移的关系  

Relationship between VEGF-C with Lymphatic Vessel Density and Lymph Node Metastasis in Non-small Cell Lung Cancer

作　　者：杜岩[1] 秦建文[1] 周静敏[1] 李月川[1] 陈宝元[2] 

机构地区：[1]天津市胸科医院胸内科,300051 [2]天津医科大学总医院呼吸内科

出　　处：《天津医药》2009年第9期737-739,共3页Tianjin Medical Journal

摘　　要：目的:探讨血管内皮细胞生长因子(VEGF)-C在非小细胞肺癌(NSCLC)淋巴管生成和淋巴结转移中的作用。方法:采集NSCLC标本62例及正常肺组织10例,应用非生物素二步法检测VEGF-C蛋白在组织中的表达,D2-40标记淋巴管内皮细胞以计数淋巴管密度(LVD)。结果:NSCLC组VEGF-C蛋白表达阳性率及淋巴管密度高于正常肺组织组(P分别为0.004、0.000);VEGF-C蛋白表达与年龄、性别、病理类型无关(P分别为0.102、0.387、0.121);而与肿瘤大小、淋巴结转移、淋巴管密度及临床分期有关(P分别为0.005、0.002、0.002、0.000),淋巴结转移与VEGF-C蛋白表达及淋巴管密度有关(P分别为0.004、0.002)。结论:VEGF-C在NSCLC表达增高,并诱导NSCLC的淋巴管生成,从而促进NSCLC的淋巴结转移,是评估预后和制定治疗措施的重要指标。Objective： To investigate the possible mechanism of lymphangiogenesis and lymph node metastasis by detecting the expressive levels of vascular endothelial growth factor （VEGF）-C in non-small cell lung cancer （NSCLC）. Methods： The expressions of VEGF-C and D2-40 were detected in 62 paraffin sections of NSCLC and 10 normal lung tissues by immunohistochemistry method.Assessments of lymphatic vessel density（LVD） and positive rates of VEGF-C were performed and their relationship were analysed.Results： The positive rates of VEGF-C and LVD were significantly higher in NSCLC group than those in the normal lung tissue group （P = 0.004 and 0.000）. No correlations were found between the expression of VEGF-C and age, gender, and histological type （P = 0.102, 0.387 and 0.121）. There was a correlation between VEGF-C and tumor diameter, lymph node metastasis, LVD and TNM stage （P = 0.005, 0.002, 0.002 and 0.000）. The correlations were also found between lymph node metastasis, VEGF-C and LVD （P = 0.004 and 0.002）. Conclusion： VEGF-C may mediate lymph node metastasis of NSCLC by the way of inducing lymphangiogenesis, and may serve as prognostic indicators and guide the treatment.

关 键 词：血管内皮生长因子C 淋巴管 淋巴转移 癌 非小细胞肺 LOGISTIC模型 

分 类 号：R735.2[医药卫生—肿瘤] R734.2[医药卫生—临床医学]