毛细支气管炎患儿血胸腺和活化调节趋化因子测定的意义  

Implication of peripheral blood thymus-and activation-regulated chemokine determination in children with bronchiolitis

作　　者：王莹[1] 陆小霞[1] 胡艳[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心,武汉430016

出　　处：《华中医学杂志》2009年第4期199-201,共3页Central China Medical Journal

摘　　要：目的探讨毛细支气管炎患儿血胸腺和活化调节趋化因子(TARC)的临床意义。方法采用ELISA方法测定毛细支气管炎急性期、恢复期和非喘息性肺炎患儿外周血中TARC的浓度。结果毛细支气管炎患儿急性期血TARC的水平显著高于非喘息性肺炎患儿(P<0.01)。毛细支气管炎恢复期患儿血清TARC水平较急性期明显降低(P<0.01),但仍高于非喘息性肺炎患儿的水平,有显著性差异(P<0.05)。结论TARC在毛细支气管炎的发病机制中有不可忽视的作用,TARC拮抗剂在毛细支气管炎治疗上可能有一定的作用。Objective To explore the clinical significance of peripheral blood thymus-and activation-regulated chemokine（TARC）determination in infants with bronchiolitis.Methods The level of TARC was determined in the infants with bronchiolitis in the acute and recovery stages,and the infants with no-wheezing pneumonia by ELISA.Results TARC levels in the infants with bronchiolitis in acute stage were higher than those in no-wheezing pneumonia group（P〈0.01）.The TARC levels in the infants with bronchiolitis in the convalescent stage were lower than those in acute stage（P〈0.01）,but higher than those in no-wheezing pneumonia group（P〈0.05）.Conclusion The TARC is elevated in bronchiolitis,and TARC may participate in the pathogenesis of bronchiolitis.TARC receptor antagonist may play an important role in the treatment of bronchiolitis.

关 键 词：呼吸道合胞病毒 毛细支气管炎 T辅助细胞 胸腺和活化调节趋化因子 

分 类 号：R725.6[医药卫生—儿科]