葛根总黄酮经鼻与口服给药的药代动力学研究  

Pharmacokinetics of Pueraria Flavonid Nasal Drop through nasal and oral administration

作　　者：郑彩美[1,2] 卢毅[2] 张彤[2] 陶建生[2] 

机构地区：[1]厦门医学高等专科学校,福建厦门361008 [2]上海中医药大学,上海201203

出　　处：《中成药》2009年第8期1194-1198,共5页Chinese Traditional Patent Medicine

基　　金：教育部(编号2004-20);上海市科委(06DZ19713);上海市教委重点学科资助(J50302)

摘　　要：目的:考察葛根黄酮滴鼻剂经鼻腔给药后在兔体内的药代动力学过程,并与口服给药途径进行对比研究。方法:10只新西兰大白兔随机分为两组,分别采用经鼻腔给药和口服给药(葛根黄酮106.4mg/kg),用HPLC检测,DAS2.0软件计算两种给药途径的生物利用度。结果:经鼻给药和口服给药的主要药动学参数分别为AUC(0-∞)1(30.55±4.93)mg/(L.h),(6.90±2.76)mg/(L.h);Tmax1=(0.90±0.14)h,(0.63±0.34)h;Cmax1=(11.27±1.66)mg/L,(1.68±0.84)mg/L。相对生物利用度F=442.8%。结论:葛根总黄酮滴鼻剂在兔体内的吸收好,生物利用度较高。AIM：To study pharmacokinetic of Pueraria Flavonid Nasal Drop in rabbits through nasal administration in comparison with oral administration. METHODS：Ten New Zealand rabbits were divided into two groups randomly and administrated nasally and orally （106.4 mg/kg of pueraria flavonid）. HPLC was adopted to detect pueraria flavonoid content and DAS 2.0 was used to calculate bioavailability. RESULTS：The main pharmacokinetic parameters of nasal and oral administrations were AUC （0-∞）1 =（30.55±4.93）mg/（L·h）,T max1= （0.90± 0. 14） h,Cmaxl = （ 11.27 ±1.66）mg/L;AUC（0-∞）2 = （6.90 ± 2.76） mg/（ L · h）, Tmax2 = （0.63 ±0.34） h, Cmax2 = （ 1.68 ± 0.84） mg/L. Relative bioavailability of nasal delivery was 442.8%. CONCLUSION： Pueraria Flavonoid Nasal Drop is well absorbed in rabbits and has high bioavailability.

关 键 词：葛根黄酮 药动学 生物利用度 葛根素 家兔 

分 类 号：R969.1[医药卫生—药理学]