1-(3-氯-2-吡啶基)-3-三氟甲基-1H-吡唑-5-甲酸的合成  

Synthesis of 1-(3-Chloro-2-pyridyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic Acid

作　　者：何海兵[1] 张湘宁[2] 朱红军[1] 谭海军[1] 

机构地区：[1]南京工业大学,南京210009 [2]江苏省农药研究所股份有限公司,南京210019

出　　处：《现代农药》2009年第4期25-26,30,共3页MODERN AGROCHEMICALS

摘　　要：1-(3-氯-2-吡啶基)-3-三氟甲基-1H-吡唑-5-甲酸是鱼尼丁受体杀虫剂DP-23合成的关键中间体。以3-氯-2-吡啶肼及三氟乙酰基丙酮为原料合成1-(3-氯-2-吡啶基)-3-三氟甲基-5-甲基-1H-吡唑,再经溴代、水解和氧化得到1-(3-氯-2-吡啶基)-3-三氟甲基-1H-吡唑-5-甲酸,总收率达到37.4%。1-（3-Chloro-2-pyridyl）-3-trifluoromethyl-lH-pyrazole-5-carboxylic acid is a key intermediate for the synthesis of DP-23, a new ryanodine acceptor activator insecticide. A new scheme was studied for the synthesis of it. 3-Choloro-2-hydrazinopyridine was reacted with 1-trifluoro-2,4-pentanedione, then bromined, hydrolyzed and oxidated to 1-（3-chloro-2-pyridyl）-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid. The total yield reached 37.4%.

关 键 词：杀虫剂 鱼尼丁 吡唑酸 合成 

分 类 号：TQ453.2[化学工程—农药化工]