抑脂祛痘药膜对兔耳实验性痤疮的作用  

Effects of lipid and acne inhibitive cream on acne model of rabbit's ears

作　　者：杨柳[1] 杨文志[1] 

机构地区：[1]南方医科大学中医药学院中医外科学教研室,广州510515

出　　处：《郑州大学学报（医学版）》2009年第4期769-771,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：南方医科大学科技开发基金资助项目A310423

摘　　要：目的:观察抑脂祛痘药膜对兔耳实验性痤疮的作用。方法:在16只新西兰纯种白色雄兔双侧耳管开口处2cm×2cm范围,每d外涂油酸1次,每次0.5mL,连续3周,建立兔耳实验性痤疮模型。将白兔随机分为实验组与对照组各8只。实验组外涂抑脂祛痘药膜,对照组外涂维A酸乳膏,每次1～2mL,1次/d,30min后洗去,连续2周。用药前、后对实验组和对照组实验性痤疮进行组织学分级比较。结果:实验组涂药膜2周后,局部毛囊角栓减少,部分角栓脱落后遗留点状凹陷的毛囊,丘疹变平减少;组织学观察见表皮增厚减轻,真皮炎症细胞减少,毛囊口轻度扩张,实验性粉刺改善明显。实验组用药前、后组织学分级间差异有统计学意义(Z=-3.588,P<0.001);对照组用药前、后组织学分级间差异亦有统计学意义(Z=-3.614,P<0.001)。实验组和对照组治疗前后比较差异无统计学意义(Z=-0.620,P=0.535;Z=-0.694,P=0.487)。结论:抑脂祛痘药膜对痤疮具有减少毛囊的角栓、减轻真皮炎症的作用。Aim ： To observe the effects of lipid and acne inhibitive cream （L＆AIC） on acne model of rabbit＇ s ears. Methods：A total of sixteen New Zealand white rabbits were randomly derided into the expermiental group（ n = 8） and control group（ n = 8）. Oleic acid was applied on expermiental rabbit＇s ears to establish the ache model of rabbit＇s ears. The rabbits in treatment group were smeared with L＆AIC 2 mL once perday for 2 successive weeks. And the L＆AIC was washing-out in 30 minutes. The rabbits in control group were smeared with tretinoin cream 1 mL once per day. The ears of the rabbits in both groups were observed macroscopically and histologically. Results： In expermiental group, macroscopic observation indicated that the ear skin became thinner and softer, corneous plug in local hair follicle was decreased, pitting hair follicle remained after partial failing of corneous plug, mild peeling, and papules were relived or become flat. Histological observation manifested that thickness of cuticle was relieved, mild follicularorifice was expanded lightly and a few keratinized materials was filled in. In the treatment group, macroscopic observation indicated that the ear skin became thinner and softer, corneous plug in the hair follicle was decreased, papules were relived or became flat. Histological observation manifested that mild hyperkerates was in the epidermis, a few inflammatory cell infiltrations in the dermis and a few keratinized materials were filled in the follicular orifice. There were significant differences in the expermiental group before and after treatment （Z = -3. 588, P 〈 0. 001 ） , there were significant differences in the control group before and after treatment （Z = -3. 614 ,P 〈 0. 001 ） , and there was no significant difference in the expermiental and control group before and after treatment （ Z = - 0. 620, P = 0. 535 ;Z = - 0. 694,P = 0. 487 ）. Conclusion ： L＆AIC could improve abnormal cornification of hair follicle in acne.

关 键 词：痤疮 抑脂祛痘药膜 实验性痤疮 耳 家兔 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]