血液灌流对维持性血液透析患者成纤维细胞生长因子23的影响  

Effect of Hemoperfusion on the Level of Serum Fibroblast Growth Factor 23 in Hemodialysis Patients

作　　者：张军力[1] 宦红娣[1] 张景红[1] 李萍[1] 陆蓓莉[1] 杨黄[1] 杨峻[1] 

机构地区：[1]中国人民解放军85医院肾内科,上海200052

出　　处：《中国临床医学》2009年第4期594-596,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:观察血液灌流(HP)对维持性血液透析(HD)患者血清成纤维细胞生长因子23(FGF-23)的影响及其可能的作用机制。方法:测定15例HD患者血液灌流前、后血清FGF-23、全段PTH(iPTH)及血清肌酐、钙、磷等指标。透析方案:血液灌流联合血液透析1次/2周,HD5次/2周,总共12次为1个疗程。结果:单次HP患者的血清肌酐水平均明显下降(P<0.05)。HP治疗12次后患者FGF-23(88.51±35.0ng·L-1)、血磷(87.85±33.65ng·L-1)均明显下降。结论:血液灌流可降低HD患者FGF-23水平,改善血磷代谢。Objective： To explore the effect of hemoperfusion on the level of werum fibroblast growth factor-23 in hemodialysis patients. Methods：Serum FGF23 was detected by enzyme-linked immunosorbent assy（ELISA） before and after hemoperfusion in a cohort of 15 HD patients. Serum intact PTH ,creatinine,calcium and phosphorus were also measured at the same time. Results： Serum FGF-23 was significantly higher in HD patients（534.50 ± 106.38pg/ml vs 11.76 ± 3.63 pg/ml）. After a period of hemoperfusion, serum FGF-23 and phosphorus was much downregulated,as well as iPTH and TG. Conclusion： Serum FGF-23 is significantly downregulated after a long term of hemoperfusion. Maybe it can regulate the metabolism of phosphorus.

关 键 词：成纤维细胞生长因子23 血液灌流 磷 维持性血透 

分 类 号：R459.5[医药卫生—治疗学]