缬沙坦联合胺碘酮治疗心房颤动的临床观察  

Effect of valsartan combined with amiodarone treating atrial fibrillation

作　　者：罗显洪[1] 柯尊平[2] 陈世维[1] 李雪[1] 肖湘君[1] 

机构地区：[1]丹江口市第一医院综合科,湖北丹江口442700 [2]湖北省十堰市人民医院心内科

出　　处：《心血管康复医学杂志》2009年第4期376-378,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察口服胺碘酮联合血管紧张素Ⅱ受体拮抗剂(ARB)缬沙坦治疗心房颤动的疗效,及对左心房功能的影响。方法:入选78例持续性心房颤动患者,随机分为两组,单纯口服胺碘酮(Ⅰ组)36例,口服胺碘酮+缬沙坦(Ⅱ组)42例,疗程观察24个月。结果:共75例完成治疗,随访24个月,两组患者治疗12～24个月后左心房内径Ⅰ组显著高于Ⅱ组(P<0.05);治疗后Ⅱ组窦性心律维持12～24个月的均明显高于Ⅰ组(P<0.05)。结论:口服胺碘酮联合缬沙坦可逆转左心房扩大,比单用胺碘酮能更有效地转复房颤,维持窦性心律。Objective： To investigate the efficacy of amiodarone combined angiotensin Ⅱ receptor antagonist （ARB） valsartan treating atrial fibrillation, and left atrial function. Methods： A total of 78 patients with persistent atrial fibrillation were randomly divided into two groups： simple amiodarone group （group Ⅰ , 36 cases）, amiodarone ＋ valsartan group （group Ⅱ , 42 cases）, they were treated for 24 months, following-up for 24 months. Results： Totally 75 cases completed the treatment. The left atrium in simple amiodarone group was significantly higher than that in amiodarone ＋ valsartan group 12-24 months after treated （P〈0.05） ; the maintenance rates of 12 months, 24 months of sinus rhythm in amiodarone ＋ valsartan group were significantly higher than those in simple amiodarone group （P〈 0.05）. Conclusion： Amiodarone combined valsartan can reverse expansion of left atrium, and are more effective for transfer and maintain sinus rhythm compared with simple amiodarone treatment in patients with atrial fibrillation.

关 键 词：心房颤动 胺碘酮 缬沙坦 

分 类 号：R541.75[医药卫生—心血管疾病]