肌球蛋白工作循环模型  

A four-state model of mechanochemical actin-activated myosin ATPase cycle

作　　者：王志坚[1] 杨科利[2] 许强[2] 彭艳辉[3] 

机构地区：[1]天水师范学院物理与信息科学学院物理系,甘肃天水741001 [2]宝鸡文理学院物理与信息技术系,陕西宝鸡721007 [3]东北农业大学生物物理系,黑龙江哈尔滨150030

出　　处：《宝鸡文理学院学报（自然科学版）》2009年第2期50-52,共3页Journal of Baoji University of Arts and Sciences(Natural Science Edition)

基　　金：甘肃省教育厅科研项目资助(0608-04);天水师范学院重点科研项目资助(TSA-0708)

摘　　要：目的基于肌肉的特殊结构,给出肌球蛋白工作循环的四态模型,研究肌肉中力与位移的关系。方法利用化学动力学方法及其非平衡稳态解,从物理学的角度讨论肌肉中力与位移的关系。结果力与位移的关系与实验结果基本吻合。结论此模型可用于讨论肌肉的力与位移的关系,而且化学动力学方法适用于研究本文体系。Aim A mechanochemical actin-activated myosin ATPase cycle four-state model has been proposed on the basis of the knowledge of special structure of muscle. Methods From the view of physics, lhe relationship between the average force on the binding states and the displacement of the thick filament was discussed with the chemical kinetic method and the non-equilibrium steady solution of equations. Results The theoretical results are consistent with that of experiment. Conclusion The model is fit to study the relationship between the average force on the binding states and the dis- placement of the thick filament and the chemical kinetic method is also fit to study the system in this article.

关 键 词：肌球蛋白 循环模型 化学动力学方程 

分 类 号：Q61[生物学—生物物理学]