川芎嗪对丙泊酚致小鼠学习记忆障碍的影响  

The effect of ligustrazine on propofol-induce learning deficit and dysmnesia in mice

作　　者：魏大岫[1] 佟飞[1] 高苏麟[1] 江俊男[1] 冯洁[1] 周坤坤[1] 李辰[1] 何珂[2] 王丹[3] 

机构地区：[1]徐州医学院麻醉学院,2006级2班江苏徐州221004 [2]徐州医学院临床医学一系 [3]徐州医学院麻醉药理学教研室

出　　处：《徐州医学院学报》2009年第8期504-505,共2页Acta Academiae Medicinae Xuzhou

基　　金：江苏省高校自然科学基础研究项目(08KJD320006);2007年江苏省高等学校大学生实践创新训练计划项目(396;404)

摘　　要：目的观察川芎嗪对丙泊酚致小鼠学习记忆障碍的影响。方法将小鼠分为3组:生理盐水组(NS组)、丙泊酚组(P组)和川芎嗪+丙泊酚组(LP组),每组10只。用避暗实验(step-through test)分别观察24 h后记录小鼠的潜伏期和错误次数。结果与NS组相比,P组潜伏期缩短(P<0.05),错误次数增加(P<0.05);与P组相比,LP组错误次数明显减少(P<0.01),潜伏期有增长趋势,但差异无显著性(P>0.05)。结论川芎嗪改善丙泊酚所致小鼠学习记忆障碍。Objective To investigate the effect of ligustrazine on propofol - induced learning deficit and dysmnesia in mice. Methods The mice were divided into 3 groups （n = 10） ： normal saline group （ group NS）, propofol group （ group P） and ligustrazine ＋ propofol （ group LP）. The latency and error numbers of in each group were observed by the step - through task. Results Compared with group NS, the latency of group P decreased （ P 〈 0.05 ） , while the error numbers increased （P 〈 0.05 ）. As compared to group P, the error numbers of group LP decreased （P 〈 0.01 ） and the latency showed a tendency of increase. However, the differences in latency were of no statistical significance （P 〉 0.05 ）. Conclusion Ligustrazine could improve the propofol- induced learning deficit and dysmnesia in mice.

关 键 词：川芎嗪 丙泊酚 避暗实验 学习记忆障碍 

分 类 号：R614.2[医药卫生—麻醉学]