正交设计法优选多效胃镜乳的制备工艺  

Optimization of Preparation Technology for Multi-Effect Gastroscope Emulsion by Orthogonal Design

作　　者：于西全[1] 肖华[1] 晏明[2] 

机构地区：[1]中国人民解放军南京军区福州总院药剂科,福建福州350025 [2]上海第二军医大学药学院,2005级学员上海200433

出　　处：《中国药业》2009年第17期30-31,共2页China Pharmaceuticals

摘　　要：目的优选多效胃镜乳的制备工艺。方法以乳剂的稳定性和外观为考察指标,以乳化剂用量、水相(未加单糖浆)pH和乳化温度为可变因素,用L9(34)表进行正交试验。结果最优的制备工艺是7mL乳化剂司盘-80和14g西黄蓍胶,水相(未加单糖浆)pH=4,乳化温度85℃。结论按最佳工艺制备的多效胃镜乳符合2000年版《中国药典》的规定。Objective To optimize the preparation technology for multi-effect gastroseope emulsion. Methods The stability and appearance of the emulsion were used as the evaluating targets, the orthogonal design method table L9（3^4） was used. Emulsifiers, water-phase （without simple syrup） pH and temperature of the emulsion were selected as the variable factors. Results The optimum technology was Span- 80 mL, tragacanth 14 g, water- phase （without simple syrup）pH =4 and the emulsifying temperature 85 ℃. Conclusion The multi- effect gastroscope emulsion prepared by this technology accords with the stipulation of Chinese Pharmacopoeia（2000 edtion）.

关 键 词：多效胃镜乳 正交试验 制备工艺 

分 类 号：TQ460.6[化学工程—制药化工] R944.17[医药卫生—药剂学]