影响宫腔内人工受精妊娠率的相关因素分析  

Analysis on relevant effect factors of pregnancy rate of intrauterine insemination

作　　者：刘杰[1] 郑洁[1] 程毓芝[1] 吕立群[1] 李薇[1] 孙虹[1] 夏敏[1] 

机构地区：[1]湖北省妇幼保健院生殖医学中心,湖北武汉430070

出　　处：《中国妇幼保健》2009年第25期3572-3574,共3页Maternal and Child Health Care of China

摘　　要：目的:通过对229例患者339个周期宫腔内人工授精(IUI)的总结,分析影响IUI妊娠率的主要相关因素。方法:从不孕症的病因、不孕年限、自然周期与促排卵周期、不同的促排卵方案克罗米酚(CC)组、CC+人绝经期尿促性腺激素(hMG)组、hMG组、授精时机及IUI的次数6个方面,分别进行妊娠率的比较。结果:男方因素的妊娠率(21.91%)明显高于其他因素,差异有统计学意义(P<0.05);不孕2年内的妊娠率(27.14%)明显高于不孕2年以上者,差异有统计学意义(P<0.05);促排卵周期和自然周期之间(17.98%vs13.51%)、促排卵的3组方案之间(CC组16.48%、CC+hMG组21.51%、hMG组13.64%);2次IUI和1次IUI之间(16.36%vs16.81%),排卵前1次和排卵后1次之间(11.32%vs21.21%),IUI治疗1周期和2周期及以上(16.36%vs16.81%)妊娠率差异均无统计学意义(P>0.05)。结论:IUI更适用于男方因素引起的不孕,在此基础上选择最恰当的授精时机是影响妊娠率的关键。Objective： To analyze the effect factors of pregnancy rate of intrauterine insemination （IUI） by means of analyzing 339 cycles of IUI of 229 patients. Methods ： The pregnancy rates of intrauterine insemination were compared according to six respects ： infertility reasons, length of infertility, stimulation and natural cycles, different protoeois for stimulating ovulation （ CC group, CC ＋ hMG group, h MG group） , insemination opportunity and cycle number. Results： The pregnancy rate resulting from male factors （21.91% ） was significantly higher than those from the other factors （P 〈 0. 05 ） , and the pregnancy rate with the length of infertility less than 2 years （21.91% ） was significantly higher than that with the length of infertility more than 2 years （P 〈0. 05 ） . There was no difference in the pregnancy rate between stimulation and natural cycles （ 17.98% vs 13.51% ） , the three different protocols for stimulating ovulation （ CC 16.48% , CC ＋ hMG 21.51% , hMG 13.64% ） , IUI once and twice （ 16. 81% vs 16. 36 % ） , IUI once before and ＇after ovulation （11.32% vs 21.21% ） （ P 〉 0. 05 ） . Conclusion： IUI is valuable for infertility caused by male factors. Choosing the most suitable insemination opportunity is the key to increase the pregnancy rate.

关 键 词：宫腔内人工授精 妊娠率 影响因素 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]