桑螵蛸及其粗提物对四氧嘧啶糖尿病小鼠的影响  

Effects of Ootheca Mantidis and its Extracts on Alloxan-induced Diabetic Mice

作　　者：林璐璐[1] 牛长缨[1] 雷朝亮[1] 

机构地区：[1]湖北省昆虫资源利用与害虫可持续治理重点实验室华中农业大学,湖北武汉430070

出　　处：《时珍国医国药》2009年第8期1901-1903,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家科技基础条件平台建设子项目(No.2005DKA21105)

摘　　要：目的研究桑螵蛸及其粗提物对四氧嘧啶糖尿病小鼠的影响。方法用四氧嘧啶致糖尿病小鼠模型,分别观察桑螵蛸及其粗提物对小鼠的血糖、体重、饮水量以及一般状况的影响。结果与模型组相比较,桑螵蛸高、中、低剂量组都能降低四氧嘧啶致糖尿病小鼠的血糖水平(P<0.01),改善其"三多一少"的糖尿病症状;桑螵蛸的石油醚提取物、水提物和醇提物均能降低四氧嘧啶致糖尿病小鼠的血糖水平,但石油醚提取物的作用最为显著(P<0.01),其次是水提物(P<0.05),醇提物的作用最不明显。结论桑螵蛸对四氧嘧啶糖尿病小鼠具有良好的治疗作用,且其活性成分主要存在于石油醚提取物中。Objective To observe the effects of Ootheca Mantidis and its extracts on alloxan - induced diabetic mice. Methods The model of diabetic mice was induced by alloxan, and the effects of Ootheca Mantidis （OM） and its extracts on blood sugar, weight, water - intake and general status were observed. Results （ 1 ） The high dose group, the middle dose group and the low dose group of OM all could decrease the blood sugar of mice induced by alloxan （P 〈 0.01 ）, symptoms such as polydipsia, diabetes and polyphagia abated. （2） Compared with control groups, the water extract（P 〈0.05） ,the ethanol extract and the petroleum ether extract（ P 〈 0.01 ） of OM all could decrease the blood sugar of mice induced by alloxan, but the effect of the ethanol extract was not obvious. Conclusion Ootheca Mantidis has a good therapeutic effect on alloxan - induced - diabetic mice, and its active component mostly exists in the petroleum ether extract from Ootheca Mantidis.

关 键 词：桑螵蛸 粗提物 四氧嘧啶 小鼠 血糖 

分 类 号：R285.5[医药卫生—中药学]