负载于孔道内部的手性酸碱催化不对称Aldol反应  

Chiral Diamine/Brφnsted Acid Conjugates Confined in Mesoporous Silica as Catalyst for the Asymmetric Aldol Reaction

作　　者：李华[1] 吕小兵[1] 

机构地区：[1]大连理工大学精细化工国家重点实验室,辽宁大连116012

出　　处：《催化学报》2009年第7期587-589,共3页

基　　金：全国优秀博士论文专项基金(200759);国家杰出青年科学基金(20625414)

摘　　要：将手性的伯胺-叔胺与B酸组成的酸碱对负载到介孔材料SBA-15孔道的内表面,得到了一种非均相双功能催化剂.该催化剂在催化丙酮和不同醛的aldol反应时得到了中等的活性和对映体选择性,重复使用6次后活性没有明显下降.与以硅胶为载体的催化剂相比,以介孔SBA-15分子筛为载体的催化剂ee值更高,这可能是由于介孔孔道限制效应引起的.Chiral primary-tertiary diamine/Brφnsted acid conjugates were selectively immobilized on the inner surface of mesoporous silica and used as catalyst for the asymmetric aldol reaction of acetone with various aldehydes. The catalyst showed modest reactivity and enantioselectivity and can be reused 6 times without loss of activity and enantioselectivity. As compared with silica gel as the support, an increase in ee value of the reaction product was observed with the SBA-15-immobilized organic catalyst. This was believed to be due to the confinement effect of the nanopores.

关 键 词：手性催化 固载化 限制效应 双功能催化剂 醛酮缩合反应 

分 类 号：O643.32[理学—物理化学]